Drawing upon township-level data on high-tech firms of Nanjing, China, this paper adopts a spatial econometric approach to examining the existence of spatial dependence and heterogeneity in the location processes of high-tech firms. The results show that some locational determinants of neighbouring townships exert significant impacts on the attractiveness of a certain township for high-tech firms. Besides, the marginal effects of some locational determinants are found to vary across space. In general, these results point to the need to account for both inter-territorial spillovers and cross-spatial variance in the investigation of factors that influence high-tech firm location.JEL classification: C31, R30