Journal of Cell Biology volume 216, issue 2, P317-330 2017 DOI: 10.1083/jcb.201609124 View full text
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Oguzhan Atay, Jan M. Skotheim

Abstract: Recent studies show that MAPK pathways perform exquisite spatial and temporal signal processing. This review discusses the mechanisms that process dynamic inputs into graded output responses, the role of positive and negative feedbacks, and feedforward regulation.