Speaker Presentations 2017
DOI: 10.1136/annrheumdis-2017-eular.7134
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Abstract: The type I interferon (IFN) system is our main defense against viral infections and can be activated by a large number of sensors of nucleic acid, triggering the production of more than 15 different proteins with antiviral and immunostimulatory capacity. There are several observations suggesting an important role for this system in the etiopathogenesis of SLE and other autoimmune diseases. Among these are the reported development of autoimmune diseases during treatment with IFN-alpha, a prominent increase in t… Show more

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Cited by 67 publications
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“…IFN-I production is tightly regulated such that levels are virtually undetectable in health. However, during pro-inflammatory states, such as viral infections, IFN-I is rapidly produced in large quantities 41. Especially notable in their propensity to secrete IFN-I are plasmacytoid dendritic cells (pDCs), which abundantly express intracellular pattern recognition receptors such as toll-like receptor (TLR)-7 and TLR-9 42…”
Section: The Type I Ifn Axismentioning
confidence: 99%
See 1 more Smart Citation
“…IFN-I production is tightly regulated such that levels are virtually undetectable in health. However, during pro-inflammatory states, such as viral infections, IFN-I is rapidly produced in large quantities 41. Especially notable in their propensity to secrete IFN-I are plasmacytoid dendritic cells (pDCs), which abundantly express intracellular pattern recognition receptors such as toll-like receptor (TLR)-7 and TLR-9 42…”
Section: The Type I Ifn Axismentioning
confidence: 99%
“…Furthermore, the ISGs are upregulated in several disease states, most notably systemic lupus erythematosus (SLE), where their expression correlates with more severe disease. They are also upregulated in primary Sjögren’s syndrome, systemic sclerosis and a subset of patients with RA 41. Indeed, the potent IFN-I production by pDCs observed following TLR-7/9 ligation by endogenous nucleic acid complexes provides a potential mechanistic basis to explain the provenance of the cytokine in the pathogenesis of SLE, where therapeutic strategies to block the IFN-I pathway are currently in development (see online supplementary Table S1).…”
Section: The Type I Ifn Axismentioning
confidence: 99%
“…Systemic lupus erythematosus (SLE) in patients and mouse models is characterized by the production of pathogenic antinuclear autoantibodies (ANAs) [13]. These ANAs form immune complexes which promote inflammation and tissue damage.…”
Section: Introductionmentioning
confidence: 99%
“…Type I IFNs and particularly IFN-α have emerged as key pathogenic cytokines in SLE (11,12). Elevated IFN-α is observed in over 50% of patients and correlates with disease severity, flare, and tissue involvement.…”
Section: Introductionmentioning
confidence: 99%