Soy Intervention in Adolescent Girls: Design and Implementation

Oshiro, Caryn; Maskarinec, Gertraud; Petitpain, Debra; Hebshi, Sandra; Novotny, Rachel

doi:10.1016/s1499-4046(06)60235-2

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Twice during the study, memos of encouragement and nutrition games were mailed to the subjects. The details of the educational strategy have been described elsewhere (Oshiro et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Urinary isoflavone excretion as a compliance measure in a soy intervention among young girls: a pilot study

et al. 2004

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Objective: To investigate the compliance of young girls with a soy intervention. Design: An 8-week dietary intervention and urine sample collection. Setting: Free-living girls. Subjects: A convenience sample of 8-to 14-y-old girls (20 started and 17 finished the study) recruited through flyers distributed to staff members and previous study participants. Intervention: The girls consumed one daily serving of soymilk, soy nuts, or tofu, completed 3-day food records, kept daily soy intake logs, and collected weekly urine samples. Main outcome measures: Compliance with the intervention was evaluated by daily soy intake logs, 3-day food records analyzed by the center's Food Composition and Food Groups Servings Databases, and weekly urinary isoflavone excretion using high-pressure liquid chromatography. The statistical analysis included paired t-tests, analysis of variance, and Spearman's rankorder correlation coefficients. Results: Daily soy intake logs indicated a mean intake of 6.28 servings out of a maximum of 7.0 servings per week. The food records revealed a six-fold increase in isoflavone intake during the study period (Po0.01) which was confirmed by an increase in urinary isoflavone excretion of similar magnitude (23.3-142.1 nmol/mg creatinine, P ¼ 0.02). Conclusions: This study demonstrated the ability of young girls to consume one daily soy serving and the usefulness of urinary isoflavones as a primary compliance measure. The high urinary isoflavone excretion levels detected in girls as compared to adult women suggest less intestinal degradation and/or greater absorption of isoflavones in nonadult populations. This finding requires further investigations into the pharmacokinetics of isoflavones.

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“…Twice during the study, memos of encouragement and nutrition games were mailed to the subjects. The details of the educational strategy have been described elsewhere (Oshiro et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Urinary isoflavone excretion as a compliance measure in a soy intervention among young girls: a pilot study

et al. 2004

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Acceptability of Soymilk as a Calcium-Rich Beverage in Elementary School Children

Reilly¹,

Lanou²,

Barnard³

et al. 2006

Journal of the American Dietetic Association

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Urinary Sex Steroid Excretion Levels During a Soy Intervention Among Young Girls: A Pilot Study

Maskarinec¹,

Morimoto²,

Novotny³

et al. 2005

Nutrition and Cancer

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Soy intake early in life may protect against breast cancer later in life, possibly by altering sex hormone metabolism. We evaluated the feasibility of assessing urinary sex steroid excretion among 20 young girls aged 8-14 yr in an 8-wk trial. The girls consumed one daily soy serving, collected weekly overnight urine samples, and reported Tanner stages for breast and pubic hair development. Sex steroid excretion was measured in duplicate by gas chromatography-mass spectrometry and adjusted for urinary creatinine. The respective coefficients of variation for estrone, estradiol, estriol, testosterone, pregnanediol were 11.4%, 10.4%, 8.4%, 12.8%, and 4.6%. The statistical analysis included t-tests, Spearman's correlations, and analysis of variance. Seventeen girls completed the study and showed good compliance with the intervention strategy. We observed nonsignificant increases in total androgens (0.11 microg/mg creatinine) and total estrogens (0.001 microg/mg creatinine) and a nonsignificant decrease in pregnanediol (-0.03 microg/mg creatinine) during the study period. Higher Tanner stages for pubic hair development were associated with ninefold higher estrogen, fourfold higher androgen, and twofold higher pregnanediol excretions (P=0.01, P<0.001, and P=0.047, respectively). Similar differences were observed after stratification by breast development and menarcheal status. The association of sex steroid levels with pubertal development supports the validity of the sex steroid measurements.

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Soy Intervention in Adolescent Girls: Design and Implementation

Cited by 3 publications

References 8 publications

Urinary isoflavone excretion as a compliance measure in a soy intervention among young girls: a pilot study

Urinary isoflavone excretion as a compliance measure in a soy intervention among young girls: a pilot study

Acceptability of Soymilk as a Calcium-Rich Beverage in Elementary School Children

Urinary Sex Steroid Excretion Levels During a Soy Intervention Among Young Girls: A Pilot Study

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