South American Blastomycosis or Paracoccidioidomycosis

Ta, Furtado; Jw, Wilson

doi:10.1001/archderm.1954.01540200026003

Cited by 15 publications

(2 citation statements)

References 8 publications

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“…Paracoccidioidomycosis (PCM), also known as South American blastomycosis, was first described by Adolpho Lutz in Brazil in 1908 who identified the disease in two patients with oral mucosal lesions and cervical lymphadenopathy [ 135 ]. Although PCM was attributed to P. brasiliensis , phylogenetic studies have identified various species within the Paracoccidioides species complex, although no distinction in clinical manifestations have been definitively established [ 136 ].…”

Section: Thermally Dimorphic Endemic Mycosesmentioning

confidence: 99%

Of Mycelium and Men: Inherent Human Susceptibility to Fungal Diseases

Vinh

2023

Pathogens

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In medical mycology, the main context of disease is iatrogenic-based disease. However, historically, and occasionally, even today, fungal diseases affect humans with no obvious risk factors, sometimes in a spectacular fashion. The field of “inborn errors of immunity” (IEI) has deduced at least some of these previously enigmatic cases; accordingly, the discovery of single-gene disorders with penetrant clinical effects and their immunologic dissection have provided a framework with which to understand some of the key pathways mediating human susceptibility to mycoses. By extension, they have also enabled the identification of naturally occurring auto-antibodies to cytokines that phenocopy such susceptibility. This review provides a comprehensive update of IEI and autoantibodies that inherently predispose humans to various fungal diseases.

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Section: Thermally Dimorphic Endemic Mycosesmentioning

confidence: 99%

Of Mycelium and Men: Inherent Human Susceptibility to Fungal Diseases

Vinh

2023

Pathogens

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“…Symmers reported that mycoses were observed “very exceptionally, in the absence of any recognized predisposing disease.” 9 Contemporary reports of neonatal sepsis with Aspergillus sydowi (sic) in multiple organs, 7 or chronic, progressive, disseminated disease with Trichophyton purpureum Bang in an otherwise healthy adult 10 exemplify these rare, sporadic occurrences. Indeed, ~50 years earlier, historical cases of severe or disseminated disease enabled the sentinel isolation and identification of thermally dimorphic, endemic fungi by medical mycology's pioneers, including blastomycosis by Gilchrist, 11 coccidioidomycosis by Posadas and Wernicke, 12 histoplasmosis by Darling, 13 paracoccidioidomycosis by Lutz, 14 and talaromycosis by the teams of Segretain 15 and Jayanetra 16 . These rare, singular cases were also an indication of an unusual diathesis.…”

Section: Opportunists Looking For An Opportunitymentioning

confidence: 99%

From Mendel to mycoses: Immuno‐genomic warfare at the human–fungus interface

Vinh

2023

Immunological Reviews

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SummaryFungi are opportunists: They particularly require a defect of immunity to cause severe or disseminated disease. While often secondary to an apparent iatrogenic cause, fungal diseases do occur in the absence of one, albeit infrequently. These rare cases may be due to an underlying genetic immunodeficiency that can present variably in age of onset, severity, or other infections, and in the absence of a family history of disease. They may also be due to anti‐cytokine autoantibodies. This review provides a background on how human genetics or autoantibodies underlie cases of susceptibility to severe or disseminated fungal disease. Subsequently, the lessons learned from these inborn errors of immunity marked by fungal disease (IEI‐FD) provide a framework to begin to mechanistically decipher fungal syndromes, potentially paving the way for precision therapy of the mycoses.

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