Source localization of event-related potentials to pitch change mapped onto age-appropriate MRIs at 6months of age

Hämäläinen, Jarmo A.; Ortiz-Mantilla, Silvia; Benasich, April A.

doi:10.1016/j.neuroimage.2010.10.016

Cited by 53 publications

(71 citation statements)

References 59 publications

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“…Equivalent current dipole models were examined first and CLARA (Classic LORETA Recursively Applied; Hoechstetter et al, 2010;Hämäläinen et al, 2011) distributed source models were used as the confirmation method. Analyses were carried out for time windows showing group differences.…”

Section: Discussionmentioning

confidence: 99%

Event-related potentials to tones show differences between children with multiple risk factors for dyslexia and control children before the onset of formal reading instruction

Hämäläinen

Lohvansuu

Ervast

et al. 2015

International Journal of Psychophysiology

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Event-related potentials to tones show differences between children with multiple risk factors for dyslexia and control children before the onset of formal reading instruction Hämäläinen, Jarmo; Lohvansuu, Kaisa; Ervast, Leena; Leppänen, Paavo H.T.Hämäläinen, J., Lohvansuu, K., Ervast, L., & Leppänen, P. (2015). Event-related potentials to tones show differences between children with multiple risk factors for dyslexia and control children before the onset of formal reading instruction. AbstractMultiple risk factors can affect the development of specific reading problems or dyslexia. In addition to the most prevalent and studied risk factor, phonological processing, also auditory discrimination problems have been found in children and adults with reading difficulties. The present study examined 37 children between the ages of 5 and 6, 11 of which had multiple risk factors for developing reading problems. The children participated in a passive oddball EEG experiment with sinusoidal sounds with changes in sound frequency, duration, or intensity. The responses to the standard stimuli showed a negative voltage shift in children at risk for reading problems compared to control children at 107-215 ms in frontocentral areas corresponding to P1 offset and N250 onset. Source analyses showed that the difference originated from the left and right auditory cortices. Additionally, the children at risk for reading problems had a larger late discriminative negativity (LDN) response in amplitude for sound frequency change than the control children. The amplitudes at the P1-N250 time window showed correlations to letter knowledge and phonological identification whereas the amplitudes at the LDN time window correlated with verbal short-term memory and rapid naming. These results support the view that problems in basic auditory processing abilities precede the onset of reading instruction and can act as one of the risk factors for dyslexia.

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Section: Discussionmentioning

confidence: 99%

Event-related potentials to tones show differences between children with multiple risk factors for dyslexia and control children before the onset of formal reading instruction

Hämäläinen

Lohvansuu

Ervast

et al. 2015

International Journal of Psychophysiology

Self Cite

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“…Using the BrainVoyager QX program the average brain template was aligned and transformed into Talairach space. Original individual and average (template) MRIs were imported into BESA Research 5.3 software for source localization of the ERP generators using age-appropriate parameters for thickness (skull: 1.5 mm; scalp: 2.5 mm; subarachnoid space: 1.7 mm) and conductivity (skull bone: 0.0581) of the infant structures (for a complete description of the technique used, please refer to Hämäläinen et al, 2011;.…”

Section: Methodsmentioning

confidence: 99%

Enhancement of Gamma Oscillations Indicates Preferential Processing of Native over Foreign Phonemic Contrasts in Infants

et al. 2013

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Young infants discriminate phonetically relevant speech contrasts in a universal manner, that is, similarly across languages. This ability fades by 12 months of age as the brain builds language-specific phonemic maps and increasingly responds preferentially to the infant's native language. However, the neural mechanisms that underlie the development of infant preference for native over non-native phonemes remain unclear. Since gamma-band power is known to signal infants' preference for native language rhythm, we hypothesized that it might also indicate preference for native phonemes. Using high-density electroencephalogram/event-related potential (EEG/ERP) recordings and source-localization techniques to identify and locate the ERP generators, we examined changes in brain oscillations while 6-month-old human infants from monolingual English settings listened to English and Spanish syllable contrasts. Neural dynamics were investigated via single-trial analysis of the temporal-spectral composition of brain responses at source level. Increases in 4 -6 Hz (theta) power and in phase synchronization at 2-4 Hz (delta/theta) were found to characterize infants' evoked responses to discrimination of native/non-native syllable contrasts mostly in the left auditory source. However, selective enhancement of induced gamma oscillations in the area of anterior cingulate cortex was seen only during native contrast discrimination. These results suggest that gamma oscillations support syllable discrimination in the earliest stages of language acquisition, particularly during the period in which infants begin to develop preferential processing for linguistically relevant phonemic features in their environment. Our results also suggest that by 6 months of age, infants already treat native phonemic contrasts differently from non-native, implying that perceptual specialization and establishment of enduring phonemic memory representations have been initiated.

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“…MMN reflects the change detection process for a deviating sound. It has been shown to be relatively stable over the course of lifetime, being highly comparable with the adult response by early school-age ( eponien et al, 1998;Hämäläinen et al, 2011). However, in infancy its correspondence is sometimes called a mismatch response (MMR), because the polarity of the response can also be positive Dehaene-Lambertz, 2000;Morr, Shafer, Kreuzer, & Kurtzberg, 2002).…”

Section: The Development Of Auditory Erp Componentsmentioning

confidence: 99%

Enhancement of brain event-related potentials to speech sounds is associated with compensated reading skills in dyslexic children with familial risk for dyslexia

Lohvansuu

Hämäläinen

Tanskanen

et al. 2014

International Journal of Psychophysiology

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Source localization of event-related potentials to pitch change mapped onto age-appropriate MRIs at 6months of age

Cited by 53 publications

References 59 publications

Event-related potentials to tones show differences between children with multiple risk factors for dyslexia and control children before the onset of formal reading instruction

Event-related potentials to tones show differences between children with multiple risk factors for dyslexia and control children before the onset of formal reading instruction

Enhancement of Gamma Oscillations Indicates Preferential Processing of Native over Foreign Phonemic Contrasts in Infants

Enhancement of brain event-related potentials to speech sounds is associated with compensated reading skills in dyslexic children with familial risk for dyslexia

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