2015
DOI: 10.1002/mc.22300
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Abstract: Activation of the sonic hedgehog (Shh) signaling pathway controls tumorigenesis in a variety of cancers. Here, we show a role for Shh signaling in the promotion of epithelial-to-mesenchymal transition (EMT), tumorigenicity, and stemness in the bladder cancer. EMT induction was assessed by the decreased expression of E-cadherin and ZO-1 and increased expression of N-cadherin. The induced EMT was associated with increased cell motility, invasiveness, and clonogenicity. These progression relevant behaviors were a… Show more

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Cited by 101 publications
(103 citation statements)
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References 37 publications
(44 reference statements)
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“…Sonic hedgehog (Shh) signaling is stimulated by TGF-β and regulates fibroblast function [161]. On the other hand, both EMT and Shh signaling are induced by TGF-β in bladder cancer [162]. Recently proteome profiling of urine samples from bladder cancer patients associated with Schistosoma haematobium infection [163] revealed further strong evidence of the proposed multi-sequence carcinogenesis process [17,18].…”
Section: In Vitro and In Vivo Evidencementioning
confidence: 99%
“…Sonic hedgehog (Shh) signaling is stimulated by TGF-β and regulates fibroblast function [161]. On the other hand, both EMT and Shh signaling are induced by TGF-β in bladder cancer [162]. Recently proteome profiling of urine samples from bladder cancer patients associated with Schistosoma haematobium infection [163] revealed further strong evidence of the proposed multi-sequence carcinogenesis process [17,18].…”
Section: In Vitro and In Vivo Evidencementioning
confidence: 99%
“…Shh signaling plays a fundamental role in cell differentiation, cell proliferation, and tissue polarity (Liu and Bain, 2014;Gomes et al, 2015;Islam et al, 2015). To investigate the effect of MeCP2 on Shh signaling in SMMC-7721 cells, we firstly examine the expression profiles of patched1 (PTCH1), a major component of the Shh pathway, as well as Shh and GLI1.…”
Section: Mecp2 Modulates the Shh Signaling Pathway In Smmc-7721 Cellsmentioning
confidence: 99%
“…39 There are also numbers of research revealed that Curcumin has specific regulation to Hedgehog signaling pathway and EMT process 7,40,41 in several cancer cells including pancreas, colon, leukemia, prostate carcinoma and glioblastomas. 8,[42][43][44] Islam SS et al and Xu X et al 9,10 point out that the Hedgehog signaling pathway activates EMT process to promote tumorigenicity and stemness. It is potent that Tsai, C. L.…”
Section: Discussionmentioning
confidence: 99%
“…7,8 And Curcumin could also prevent the EMT in different tumor cells. 9,10 With the interruption of EMT, Curcumin might cover the shortage of g-irradiation (induction of EMT). In this research, we had experiments on LN229 and U251 cells, which represented to be sensitive and insensitive to cytotoxic effect of g-irradiation, respectively.…”
Section: Introductionmentioning
confidence: 99%