Some Sensory Nerve Endings in the Skin

Winkelmann, R. K.

doi:10.1001/archderm.1955.01540270085012

Cited by 14 publications

(4 citation statements)

References 9 publications

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“…The innervation of the normal gingiva has also been investigated (Bradlaw, 1936(Bradlaw, , 1939Gairns and Aitchison, 1950;Rapp et al, 1957;Stewart and Lewinsky, 1939). Encapsulated and unencapsulated endings have been described which are similar to those reported in the skin by Weddell (1941), Winkelmann (1955) and Woollard (1936). Fig.…”

Section: Introductionsupporting

confidence: 79%

Some Abnormalities in the Nerve Supply of the Oral Mucosa

Marsland

Fox

1958

Proceedings of the Royal Society of Medicine

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Section: Introductionsupporting

confidence: 79%

Some Abnormalities in the Nerve Supply of the Oral Mucosa

Marsland

Fox

1958

Proceedings of the Royal Society of Medicine

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“…Early itch studies used spicules of cowhage to show that the strongest itch is felt in the dermo-epidermal juncture area, the area where unmyelinated sensory fibers innervate [10,26]. Five percent of the C-fibers innervating the skin react to puritogenic application, with distinct populations of C-fibers corresponding to itch in individual nerve C-fiber recordings in humans [24,27].…”

Section: Reviewmentioning

confidence: 99%

Molecular signaling and targets from itch: lessons for cough

LaVinka

Dong

2013

Cough

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Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation. This common inflammation and interaction with mast cells are involved in the development of chronic conditions of itch and cough. In this review, we examine the anatomy and molecular mechanisms of itch and compare them to known mechanisms for cough. Highlighting the common aspects of itch and cough could lead to new thoughts and perspectives in both fields.

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“…They found that inserting the spicula in the dermo‐epidermal juncture area induced the strongest itch. Winkelmann showed this to be the location the location of sensory unmyelinated nerve fibers in the skin (3). In mid 1960s Melzak and Wall proposed a gate theory showing how stimulation of pain inhibits itch (4).…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomy and neurophysiology of itch

Wallengren

2005

Dermatologic Therapy

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The specific pathway of "pure", histaminergic, itch is traced from the mechanoinsensitive nerve fibers in the skin to their central cortical projections. Neuropathic itch created at different levels of this anatomical pathway is reviewed. In this review we discuss damage to pruritoceptors in the skin, entrapment syndromes, damage to spinal ganglia, nerve root impingement, injury of the spinal cord and cerebral damage in the distribution of the middle cerebral artery, capsula interna or thalamus. Itch in inflamed skin resulting from interactions between nerve transmitters and other mediators of inflammation is described.

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Some Sensory Nerve Endings in the Skin

Cited by 14 publications

References 9 publications

Some Abnormalities in the Nerve Supply of the Oral Mucosa

Some Abnormalities in the Nerve Supply of the Oral Mucosa

Molecular signaling and targets from itch: lessons for cough

Neuroanatomy and neurophysiology of itch

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