1978
DOI: 10.1007/bf01914651
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Abstract: Incubation of human serum or plasma at 37 ~ leads to the formation of a non-dialysable vasoactive factor, which we have called active pressor principle (APP). The intravenous injection of incubated human serum into anesthetized ganglionic blocked rats causes a transient blood pressure increase similar to the response to angiotensin II. The pressure activity of incubated serum or plasma depends on temperature and time of the incubation. At 37 cC the activity reaches a maximum within 6 days. A slight decrease oc… Show more

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Cited by 9 publications
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“…Incubated plasma is known to contain vasoactive compounds in rats and guinea pigs 15 . LPA has been assumed to be an active component of the pressor response because abundant LPA is accumulated in incubated plasma by the action of ATX.…”
Section: Resultsmentioning
confidence: 99%
“…Incubated plasma is known to contain vasoactive compounds in rats and guinea pigs 15 . LPA has been assumed to be an active component of the pressor response because abundant LPA is accumulated in incubated plasma by the action of ATX.…”
Section: Resultsmentioning
confidence: 99%