Some pharmacological and toxicological studies on Balanites aegyptiaca bark

Abstract

The aqueous extract of Balanites aegyptiaca bark, which is used in Sudanese folk medicine in the treatment of jaundice, was without effect when studied on rabbit intestine, rabbit aortic strip, rat stomach strip, rat uterus and rat phrenic nerve-diaphragm in a dose up to 10 mg/mL gut bath. In a larger dose (25 mg) the extract decreased significantly the contractility and the rate of the isolated perfused rabbit heart. Administration of the aqueous extract to biliary duct-ligated rats, showed a dose-dependent significant decrease in serum bilirubin level. The chronic and subchronic toxicity investigations indicate the safety of the aqueous extract at a dose level which showed a significant decrease in serum bilirubin level in experimental obstructive jaundice in rats.

PHYTOCHEMISTRY AND PHARMACEUTICAL EVALUATION OF Balanites aegyptiaca: AN OVERVIEW

“…Though drug obtained from plant have limited chances of side but sometime improper dose can cause adverse effect of humans. Therefore toxicological study of various phytochemicals is must, Mariam et al (2013) studied the toxicological effect of B. aegyptiaca, and Jaundice, anthelmintic, rheumatism, CNS depressant, fungicidal, larvicidal, molluscicidal, insecticidal properties, it also used to remove intestinal parasites Neuwinger, 1996;Mohamed et al, 1999, Koko et al, 2000Koko et al, 2005;Chapagain et al, 2009;Patil et al, 2010;Abdulmalik et al, 2011;Shalaby et al, 2012 Stem/Root Bark Yellow fever, jaundice, antiangiogenic, antitumor, antioxidant, antimalarial, anti trypanocidal activity, cytotoxicity, mental diseases, diarrhea, epilepsy, treatment of Syphilis round worm infection, haemorrhoid, fish poison, antivinom against viper venom and syphilis Bukar et al, 2004;Katewa et al, 2004;Wurochekke & Nok, 2004;Koch et al, 2005;Gad et al, 2006;Ojo et al, 2006;Wufem et al, 2007;Ahmad Hassan et al, 2016 Fruit Skin diseases, sleeping sickness, oral hypoglycemia, cytotoxicity, antitumor effects, antioxidant, antifertility, insecticidal activity, anticonvulsant effect, cure mouth ulcer, boils and burns, whooping cough, effective antischistosomal remedy, act as an antidote to arrow poison Rao et al, 1997;Wiesman & Chapagain, 2003;Katewa et al, 2004;Koch et al, 2005;Koko et al, 2005;Gad et al, 2006;Ojo et al, 2006;Gnoula et al, 2008;Thirupathi et al, 2009;Al-Ghannam et al, 2013;Molla et al, 2013;Wabale, 2017 Seed Antitumor, anti-cancer antibacterial, antioxidant, antimalarial activity, effective antischistosomal remedy and cure cough, colic pain Wiesman & Chapagain, 2003;Bukar et al, 2004;Koko e...…”

“…A bioactive substance is defined as a constituent possessing an effect on causes of a reaction, or trigger of a response in the living tissue (Abdelkarim et al, 2014). The bark, fruit and oil of tree have been widely used to treat various disease or disorders such as cancer (Gnoula et al, 2008;Hassan et al, 2016;Montasser et al, 2017), tuberculosis (Hassan et al, 2016), HIV/AIDS (Sheded et al, 2006;Alashaal et al, 2010), malaria (Kusch et al, 2011;Bobbo et al, 2016;Sibhat & Hiben, 2016), diabetes (Helal et al, 2013;Abou Khalil et al, 2016), sleeping sickness (Barley, 1962;Sheded et al, 2006;Alashaal et al, 2010), wounds (Chevallier et al, 2003;Kommu et al, 2013), colds, syphilis, liver and spleen disorders (Abdel-Kader et al, 2008;Zaahkouk et al, 2015), jaundice (Sarker et al, 2000;Abdulmalik et al, 2011), yellow fever, snake bite (Ojo et al, 2006) and aches (Mohamed et al, 1999;Hamid et al, 2001). The infusion of root bark has been used in diarrhoea, haemorrhoid and also acts as a fish poison (Bukar et al, 2004).…”

Antiproliferative and DNA-cleaving Activities and Phytochemical Screening of Balanites roxburghiana Linn. Fruit Extracts

“…Seed is the pyrene (stone), measures as 1.5 to 3 cm long, light brown, fibrous, and tremendously hard [14] . This plant exhibited different pharmacological activities such as cardioprotective, antioxidant [15] , anthelmintic [16] , antibacterial [17] , antivenin [18] , antiinflammatory, analgesic [19] , antioxidant, xanthine oxidase and acetyl cholinesterase inhibitory [20] , antinociceptive, antioxidant [21] , mosquito larvicidal [22] , hepatoprotective [23] , antiviral [24] , wound healing [25] , hypocholesterolemia [26] , diuretic [27] , aldose reductase inhibitory [28] and antidiabetic [29] . Compounds isolated from this plant such as balanitin-6,7-saponin [30] and steroidal saponin [31] have shown anticancer activity.…”

Research Article: Pharmacological effects of the aqueous extract of Caulophyllum thalictroides (blue cohosh) on isolated Mus musculus uteri

“…In similar descriptive studies, uterine horns as opposed to the isolated myometrium have been used to successfully demonstrate contractile responses to pharmacological agonists (Ferguson and Edwards, 1954;Eno and Itam, 1998;Mohamed et al, 1999;Amos, et al, 2002;Kantas et al, 2002). Since uterine tissue is very sensitive to stretch (Kitchen, 1984), the use of full thickness strips minimizes the amount of handling.…”