Some Effects of Bufotenine and Lysergic Acid Diethylamide on the Monkey

Effects of bufotenine and p-chlorophenylalanine on reactivity to footshock

“…However, an interpretation in terms of exaggerated drive states is improbable on the basis of previous research in which B groups were no different from controls in learning goal-directed responses under similar hunger conditions (Wino cur et al, 1971). It is also unlikely that bufotenine caused an increase in general locomotion or a loss of response inhibition, since in previous investigations Es have emphasized the attenuating effects of bufotenine on locomotor behavior (Evarts, 1956;Wino cur et al, 1969).…”

Effects of bufotenine and p-chlorophenylalanine on reactivity to footshock

“…However, an interpretation in terms of exaggerated drive states is improbable on the basis of previous research in which B groups were no different from controls in learning goal-directed responses under similar hunger conditions (Wino cur et al, 1971). It is also unlikely that bufotenine caused an increase in general locomotion or a loss of response inhibition, since in previous investigations Es have emphasized the attenuating effects of bufotenine on locomotor behavior (Evarts, 1956;Wino cur et al, 1969).…”

Chemical Basis for Psychosis: Neuropharmacological Contributions to Our Present Concept.

“…Initial studies of the effects of bufotenine on the gross behavior of monkeys revealed that bufotenine induced a syndrome which was remarkably similar to the syndrome induced by LSD (11,12). Following intravenous administration of bufotenine (5 milligrams per kilogram body weight) and LSD (1 milligram per kilogram body weight) monkeys showed a gross but relatively selective alteration of behavior: diminished or absent responsiveness to visual stimuli, impairment of responses to several forms of somesthetic stimuli, but retention of responsiveness to auditory stimuli.…”

Intoxication of dogs and cats with common stimulating, hallucinogenic and dissociative recreational drugs

“…LD 50 in rats is 16.5 mg/kg IV and in mice 46–60 mg/kg IV ( Freedman, 1969 ; Passie et al., 2008 ). While these species die due to paralysis and respiratory failure, monkeys can withstand a dose of 1 mg/kg IV without any lasting somatic effects ( Evarts, 1956 ; Passie et al., 2008 ). Teratogenic effects in mice, rats and hamsters were observed in doses up to 500 μg/kg SC ( Idänpään-Heikkilä & Schoolar, 1969 ; Passie et al., 2008 ).…”

Effects of bufotenine and p-chlorophenylalanine on reactivity to footshock

“…However, an interpretation in terms of exaggerated drive states is improbable on the basis of previous research in which B groups were no different from controls in learning goal-directed responses under similar hunger conditions (Wino cur et al, 1971). It is also unlikely that bufotenine caused an increase in general locomotion or a loss of response inhibition, since in previous investigations Es have emphasized the attenuating effects of bufotenine on locomotor behavior (Evarts, 1956;Wino cur et al, 1969).…”

Chemical Basis for Psychosis: Neuropharmacological Contributions to Our Present Concept.

“…Initial studies of the effects of bufotenine on the gross behavior of monkeys revealed that bufotenine induced a syndrome which was remarkably similar to the syndrome induced by LSD (11,12). Following intravenous administration of bufotenine (5 milligrams per kilogram body weight) and LSD (1 milligram per kilogram body weight) monkeys showed a gross but relatively selective alteration of behavior: diminished or absent responsiveness to visual stimuli, impairment of responses to several forms of somesthetic stimuli, but retention of responsiveness to auditory stimuli.…”

Intoxication of dogs and cats with common stimulating, hallucinogenic and dissociative recreational drugs

“…LD 50 in rats is 16.5 mg/kg IV and in mice 46–60 mg/kg IV ( Freedman, 1969 ; Passie et al., 2008 ). While these species die due to paralysis and respiratory failure, monkeys can withstand a dose of 1 mg/kg IV without any lasting somatic effects ( Evarts, 1956 ; Passie et al., 2008 ). Teratogenic effects in mice, rats and hamsters were observed in doses up to 500 μg/kg SC ( Idänpään-Heikkilä & Schoolar, 1969 ; Passie et al., 2008 ).…”

Effects of bufotenine and p-chlorophenylalanine on reactivity to footshock

“…However, an interpretation in terms of exaggerated drive states is improbable on the basis of previous research in which B groups were no different from controls in learning goal-directed responses under similar hunger conditions (Wino cur et al, 1971). It is also unlikely that bufotenine caused an increase in general locomotion or a loss of response inhibition, since in previous investigations Es have emphasized the attenuating effects of bufotenine on locomotor behavior (Evarts, 1956;Wino cur et al, 1969).…”

Chemical Basis for Psychosis: Neuropharmacological Contributions to Our Present Concept.

“…Initial studies of the effects of bufotenine on the gross behavior of monkeys revealed that bufotenine induced a syndrome which was remarkably similar to the syndrome induced by LSD (11,12). Following intravenous administration of bufotenine (5 milligrams per kilogram body weight) and LSD (1 milligram per kilogram body weight) monkeys showed a gross but relatively selective alteration of behavior: diminished or absent responsiveness to visual stimuli, impairment of responses to several forms of somesthetic stimuli, but retention of responsiveness to auditory stimuli.…”

Intoxication of dogs and cats with common stimulating, hallucinogenic and dissociative recreational drugs

“…LD 50 in rats is 16.5 mg/kg IV and in mice 46–60 mg/kg IV ( Freedman, 1969 ; Passie et al., 2008 ). While these species die due to paralysis and respiratory failure, monkeys can withstand a dose of 1 mg/kg IV without any lasting somatic effects ( Evarts, 1956 ; Passie et al., 2008 ). Teratogenic effects in mice, rats and hamsters were observed in doses up to 500 μg/kg SC ( Idänpään-Heikkilä & Schoolar, 1969 ; Passie et al., 2008 ).…”