Somatosensory cortical activation identified by functional MRI in preterm and term infants

Arichi, Tomoki; Moraux, Antoine; Melendez, Ana Lucia Herrera; D’Oria, Valentina; Groppo, Michela; Merchant, Nazakat; Combs, Stephanie E.; Burdet, Etienne; Larkman, David J.; Counsell, Serena J.; Beckmann, Christian F.; Edwards, A. David

doi:10.1016/j.neuroimage.2009.10.038

Cited by 106 publications

(116 citation statements)

References 47 publications

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“…Mature neurovascular coupling leads to Δc playing a more dominant role than Δα _ O2 as a contributor to the hPod value. Although blood oxygenation level-dependent (BOLD) (42)(43)(44)(45)(46) and oxy-and deoxy-Hb (47,48) responses are controversial during the early development of neurovascular coupling, we speculate that the gradual changes in the value of hPod toward an antiphase pattern may reflect the increasing antiphase contribution of Δc in capillaries with angiogenesis that actively occurs in the first one-half of the first year of life after birth.…”

Section: Rapid Change Of Hpod From An In-phase To An Antiphase Pattermentioning

confidence: 95%

Hemoglobin phase of oxygenation and deoxygenation in early brain development measured using fNIRS

Watanabe

Shitara

Aoki

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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A crucial issue in neonatal medicine is the impact of preterm birth on the developmental trajectory of the brain. Although a growing number of studies have shown alterations in the structure and function of the brain in preterm-born infants, we propose a method to detect subtle differences in neurovascular and metabolic functions in neonates and infants. Functional near-infrared spectroscopy (fNIRS) was used to obtain time-averaged phase differences between spontaneous low-frequency (less than 0.1 Hz) oscillatory changes in oxygenated hemoglobin (oxy-Hb) and those in deoxygenated hemoglobin (deoxy-Hb). This phase difference was referred to as hemoglobin phase of oxygenation and deoxygenation (hPod) in the cerebral tissue of sleeping neonates and infants. We examined hPod in term, late preterm, and early preterm infants with no evidence of clinical issues and found that all groups of infants showed developmental changes in the values of hPod from an inphase to an antiphase pattern. Comparison of hPod among the groups revealed that developmental changes in hPod in early preterm infants precede those in late preterm and term infants at term equivalent age but then, progress at a slower pace. This study suggests that hPod measured using fNIRS is sensitive to the developmental stage of the integration of circular, neurovascular, and metabolic functions in the brains of neonates and infants.irth is a drastic event for the developing brain, because this is when the oxygen supply switches from the fetal-placental circulation to an autonomous system. In addition, the extrauterine environment begins to provide the neonate with a tremendous flow of stimuli. Earlier exposure to the extrauterine environment is thought to influence the developmental trajectory of the brain. It has long been known that preterm birth affects brain development and is associated with a higher rate of neurodevelopmental impairment (1). A growing number of MRI studies have shown that preterm-born neonates and infants have brain structures with aberrant volumes, morphologies, and networks at term equivalent (2, 3) and school age (4, 5). Studies of resting-state fMRI have also shown that the functional connectivity of the cortex is different in term and preterm infants (6). However, it is a matter of controversy whether neonatal MRI of the brain can predict long-term adverse outcomes, such as minor neurological dysfunction (7,8). Given the fact that preterm birth before 37 wk of gestation accounts for more than 10% of all live births (9), we need a practical and safe method to detect the status of brain development in newborns.The development of the brain involves underlying hemodynamic and metabolic changes (10). Near-infrared spectroscopy (NIRS) has been used to measure cerebral blood concentrations of oxygenated Hb (oxy-Hb) and deoxygenated Hb (deoxy-Hb) at the bedside and estimate cerebral blood volume, oxygen saturation (SO 2 ), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO 2 ) in neonates (11,12). Previous studies in pr...

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Section: Rapid Change Of Hpod From An In-phase To An Antiphase Pattermentioning

confidence: 95%

Hemoglobin phase of oxygenation and deoxygenation in early brain development measured using fNIRS

Watanabe

Shitara

Aoki

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…A number of studies have focused on the emergence of resting-state networks in fetuses and newborn infants (Alcauter et al, 2015a;Arichi et al, 2010;Fransson et al, 2009, Gao et al, 2014a, 2014b, 2009Lin et al, 2008;Schöpf et al, 2012;Smyser et al, 2010;Thomason et al, 2015). In healthy adults, a distinct set of resting-state networks has been described encompassing brain regions involved in primary functions (i.e.…”

Section: Functional Network Developmentmentioning

confidence: 99%

“…Much of our present-day knowledge about brain-behavior relationships shortly after birth comes from task-based fMRI studies (Allievi et al, 2016;Anderson et al, 2001;Arichi et al, 2013Arichi et al, , 2012Arichi et al, , 2010Born et al, 1996;Dehaene-Lambertz et al, 2010, 2002Erberich et al, 2006;Heep et al, 2009;Konishi et al, 2002;Morita et al, 2000). These studies have provided important background on the brain's responses to sensory input during the earliest phases of development of brain-behavior interactions.…”

Section: Functional Connectivity and Behavioral Counterpartsmentioning

confidence: 99%

“…These studies have provided important background on the brain's responses to sensory input during the earliest phases of development of brain-behavior interactions. Adult-like activation patterns were observed in response to a variety of sensory stimuli, including tactile and proprioceptive stimulation (passive hand movement) (Arichi et al, , 2010Erberich et al, 2006), auditory (Anderson et al, 2001), olfactory (the odor of infant formula) ) and visual input. fMRI studies in two-to three-month-old infants demonstrated leftlateralized activation of perisylvian regions including the superior temporal gyrus, angular gyrus and Broca's area in response to native-language speech (Dehaene-Lambertz et al, 2006, 2002.…”

Section: Functional Connectivity and Behavioral Counterpartsmentioning

confidence: 99%

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The emergence of functional architecture during early brain development

2017

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Early human brain development constitutes a sequence of intricate processes resulting in the ontogeny of functionally operative neural circuits. Developmental trajectories of early brain network formation are genetically programmed and can be modified by epigenetic and environmental influences. Such alterations may exert profound effects on neurodevelopment, potentially persisting throughout the lifespan. This review focuses on the critical period of fetal and early postnatal brain development. Here we collate findings from neuroimaging studies, with a particular focus on functional MRI research that interrogated early brain network development in both health and high-risk or disease states. First, we will provide an overview of the developmental processes that take place from the embryonic period through early infancy in order to contextualize brain network formation. Second, functional brain network development in the typically developing brain will be discussed. Third, we will touch on prenatal and perinatal risk factors that may interfere with the trajectories of functional brain wiring, including prenatal substance exposure, maternal mental illness and preterm

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“…Prior studies of the neonatal hemodynamic response to stimuli have yielded widely conflicting results (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). fMRI studies generally only examine changes in HbR via BOLD, whereas near infrared spectroscopy (NIRS) is a noninvasive optical technique capable of discerning HbO, HbR, and HbT changes.…”

mentioning

confidence: 99%

Resolving the transition from negative to positive blood oxygen level-dependent responses in the developing brain

Kozberg

Chen

DeLeo

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

106

137

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The adult brain exhibits a local increase in cortical blood flow in response to external stimulus. However, broadly varying hemodynamic responses in the brains of newborn and young infants have been reported. Particular controversy exists over whether the "true" neonatal response to stimulation consists of a decrease or an increase in local deoxyhemoglobin, corresponding to a positive (adult-like) or negative blood oxygen level-dependent (BOLD) signal in functional magnetic resonance imaging (fMRI), respectively. A major difficulty with previous studies has been the variability in human subjects and measurement paradigms. Here, we present a systematic study in neonatal rats that charts the evolution of the cortical blood flow response during postnatal development using exposed-cortex multispectral optical imaging. We demonstrate that postnatal-day-12-13 rats (equivalent to human newborns) exhibit an "inverted" hemodynamic response (increasing deoxyhemoglobin, negative BOLD) with early signs of oxygen consumption followed by delayed, active constriction of pial arteries. We observed that the hemodynamic response then matures via development of an initial hyperemic (positive BOLD) phase that eventually masks oxygen consumption and balances vasoconstriction toward adulthood. We also observed that neonatal responses are particularly susceptible to stimulus-evoked systemic blood pressure increases, leading to cortical hyperemia that resembles adult positive BOLD responses. We propose that this confound may account for much of the variability in prior studies of neonatal cortical hemodynamics. Our results suggest that functional magnetic resonance imaging studies of infant and child development may be profoundly influenced by the maturing neurovascular and autoregulatory systems of the neonatal brain.

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Somatosensory cortical activation identified by functional MRI in preterm and term infants

Cited by 106 publications

References 47 publications

Hemoglobin phase of oxygenation and deoxygenation in early brain development measured using fNIRS

Hemoglobin phase of oxygenation and deoxygenation in early brain development measured using fNIRS

The emergence of functional architecture during early brain development

Resolving the transition from negative to positive blood oxygen level-dependent responses in the developing brain

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