Solvent free synthesis of organoselenides under green conditions

Abstract

The organoselenides have received much interest due to their applications in medicinal chemistry, biology, material science and organic synthesis. We have presented here a comprehensive and updated review on the...

Solvent effect on the 77Se NMR chemical shifts of diphenyl diselenides

“…In this work, diphenyl diselenides popularly employed in organic synthesis were prepared, [7][8][9][10][11][12][13][14] and solubilised in different deuterated solvents to access the 77 Se NMR chemical shift profile. Additionally, the temperature and concentration dependence of the 77 Se chemical shift was investigated.…”

“…During the last few decades, organoselenium compounds have become versatile reagents in organic synthesis, 1–6 especially considering the mild conditions in which they can be prepared from electrophilic and nucleophilic chalcogen species. 7–14 Among them, selenium compounds demonstrate the greatest impact due their biological, 15–17 and catalytic applications. 18–24…”

“…During the last few decades, organoselenium compounds have become versatile reagents in organic synthesis, [1][2][3][4][5][6] especially considering the mild conditions in which they can be prepared from electrophilic and nucleophilic chalcogen species. [7][8][9][10][11][12][13][14] Among them, selenium compounds demonstrate the greatest impact due their biological, [15][16][17] and catalytic applications. [18][19][20][21][22][23][24] To provide insight into Se chemistry, 77 Se nuclear magnetic resonance (NMR) spectroscopy is a valuable experimental technique to access relevant information, such as stability, 25 reactivity, 26 and chirality, [27][28][29] as well as to investigate reaction mechanisms.…”

Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(sp2)–H Bond Selenylation of Imidazo[2,1-b]thiazole and Related Structures

“…Considering the biological relevance of organoselenium compounds and therapeutic properties of imidazoheteroarenes, molecular hybridization of these structures could lead to molecules (e.g., compound viii–xi , Figure ) with interesting biological properties. , There are several interesting methods in the literature to access such a hybrid structure. In this regard, different strategies are available in the literature for their synthesis, involving transition-metal catalysis, transition-metal-free catalytic approach, photoinduced transformation, solvent-free approach, etc. ,,, Therefore, continuous search for an alternative and greener approach involving benign solvents for the synthesis of such hybrid structure is a topic of interest.…”

“…In this regard, different strategies are available in the literature for their synthesis, involving transition-metal catalysis, transition-metal-free catalytic approach, photoinduced transformation, solvent-free approach, etc. 6b , 6c , 7 , 15 Therefore, continuous search for an alternative and greener approach involving benign solvents for the synthesis of such hybrid structure is a topic of interest.…”