Solvent-free synthesis and in-silico molecular docking study of (E)-3-(β-C-glycosylmethylidene)-N-aryl/alkyl succinimides

Abstract

Solvent-free synthesis of β-C-glycosylated methylidene succinimides using the Wittig olefination reaction and subsequent Lewis acid-mediated deprotection has been reported. Docking studies reveal that these compounds are selective and potent inhibitors of the E6 oncoprotein of high-risk type HPV16.