Solution structures of Alzheimer’s amyloid Aβ13–23 peptide: NMR studies in solution and in SDS

New Antimicrobials Based on the Adarotene Scaffold with Activity against Multi-Drug Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus

“…One of the most common models of biological membranes for NMR studies are SDS (sodium dodecylsulphate) micelles, showing a head polar group (the sulphate moiety) that mimics the surface of the membranes. Moreover, the SDS micelles have a larger correlation time with respect to the NMR time-scale and their small size allows a good spectral resolution [ 20 , 21 ].…”

Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example

“…Proton transverse relaxation time of phospholipid aggregates is too short relative to the NMR chemical shifts time-scale and leads to significant broadening of the signals in the spectra. For this reason, sodium dodecyl sulfate micelles were used as model of cell membrane, which are extensively applied in similar NMR studies (Henry and Sykes, 1994 ; Lubecka et al, 2010 ; Galiullina et al, 2012 , 2015 ; Usachev et al, 2013 ; Rakhmatullin et al, 2016 ). Head polar groups of SDS can be used to physically mimic a surface of biological membrane.…”

Grapevine stilbenoids as natural food preservatives: calorimetric and spectroscopic insights into the interaction with model cell membranes

“…40 Furthermore, the SDS polar headgroup (the sulphate moiety) mimics the membranes surface and many important phenomena which take place in bilayer membranes can be elucidated by experiments on the monolayer at an interface. 37,51 NMR experiments were conducted on water soluble derivatives, namely resveratrol 1 as monomeric compound and the two dimers (±)-trans-ε-viniferin 4 and dehydro-δ-viniferin 6, the least active and most active antimicrobial compounds, respectively. 22 Initially, we focused of the parent compound resveratrol 1, whose interactions with model membranes have already been studied by other groups.…”