Abstract:Peroxiredoxins (Prxs) are a large family of peroxidases that are found in all kingdoms of life and play a critical role in removal of reactive oxygen species (ROI), particularly hydrogen peroxide (H2O2) . Six isoforms exist in humans, with their up-regulation observed as an antioxidant defense response to treatment with toxic chemotherapeutic agents or radiation therapy . Prx3 is a mitochondrial isoform that is highly abundant in the matrix and belongs to a Prx sub-family that forms rings comprising anti… Show more
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