Soluplus micelles for acyclovir ocular delivery: Formulation and cornea and sclera permeability

Varela-García, Angela; Concheiro, Angel

doi:10.1016/j.ijpharm.2018.09.053

Cited by 71 publications

(53 citation statements)

References 40 publications

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Section: Phase Solubility Studiessupporting

confidence: 89%

“…Only the formulation prepared combining αCD 4%/βCD 3% increased the apparent solubility of ACV (36.0 mg/mL, 0.16 M). This means that ACV was not prone to be encapsulated in PF127 polymeric micelles in agreement with studies carried out with other amphiphilic copolymers [48]. Inclusion complex formation of ACV with CDs, although feasible, has been reported to cause minor enhancements in apparent solubility [49].…”

Section: Phase Solubility Studiessupporting

confidence: 86%

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Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

et al. 2020

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Acyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits both its bioavailability and antiviral performance. The combination of block copolymer micelles and cyclodextrins (CDs) may result in polypseudorotaxanes with tunable drug solubilizing and gelling properties. However, the simultaneous addition of various CDs has barely been investigated yet. The aim of this work was to design and characterize ternary combinations of Pluronic® F127 (PF127), αCD and βCD in terms of polypseudorotaxane formation, rheological behavior, and ACV solubilization ability and controlled release. The formation of polypseudorotaxanes between PF127 and the CDs was confirmed by FT-IR spectroscopy, X-ray diffraction, and NMR spectroscopy. The effects of αCD/βCD concentration range (0–7% w/w) on copolymer (6.5% w/w) gel features were evaluated at 20 and 37 °C by rheological studies, resulting in changes of the copolymer gelling properties. PF127 with αCD/βCD improved the solubilization of ACV, maintaining the biocompatibility (hen’s egg test on the chorio-allantoic membrane). In addition, the gels were able to sustain acyclovir delivery. The formulation prepared with similar proportions of αCD and βCD provided a slower and more constant release. The results obtained suggest that the combination of Pluronic with αCD/βCD mixtures can be a valuable approach to tune the rheological features and drug release profiles from these supramolecular gels.

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Section: Phase Solubility Studiessupporting

confidence: 89%

Section: Phase Solubility Studiessupporting

confidence: 86%

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

et al. 2020

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“…They also evaluated the ocular toxicity and corneal permeability at EU Reference Laboratory following US Interagency Coordinating Committee. [36,37]. J.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Effect of melt extrudability and melt binding efficiency of polyvinyl caprolactam polyvinyl acetate polyethylene glycol graft copolymer (Soluplus®) on release pattern of hydrophilic and high dose drugs

Ayyub

Moravkar

Maniruzzaman

et al. 2019

Materials Science and Engineering: C

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“…(Asteraceae), increasing its solubility and its intestinal permeability [21]. Other applications described the use of Soluplus for doxorubicin delivery in the treatment of resistant tumors [20] or to increase acyclovir permeability across the cornea and sclera [22] or even to enhance oral bioavailability and hypouricemic activity of scopoletin [23]. Numerous other applications are described in the literature [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

et al. 2019

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Posidonia oceanica (L.) Delile is a marine plant endemic of Mediterranean Sea endowed with interesting bioactivities. The hydroalcholic extract of P. oceanica leaves (POE), rich in polyphenols and carbohydrates, has been shown to inhibit human cancer cell migration. Neuroblastoma is a common childhood extracranial solid tumor with high rate of invasiveness. Novel therapeutics loaded into nanocarriers may be used to target the migratory and metastatic ability of neuroblastoma. Our goal was to improve both the aqueous solubility of POE and its inhibitory effect on cancer cell migration. Methods: Chitosan nanoparticles (NP) and Soluplus polymeric micelles (PM) loaded with POE have been developed. Nanoformulations were chemically and physically defined and characterized. In vitro release studies were also performed. Finally, the inhibitory effect of both nanoformulations was tested on SH-SY5Y cell migration by wound healing assay and compared to that of unformulated POE. Results: Both nanoformulations showed excellent physical and chemical stability during storage, and enhanced the solubility of POE. PM-POE improved the inhibitory effect of POE on cell migration probably due to the high encapsulation efficiency and the prolonged release of the extract. Conclusions: For the first time, a phytocomplex of marine origin, i.e., P. oceanica extract, has enhanced in terms of acqueous solubility and bioactivity once encapsulated inside nanomicelles.

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Soluplus micelles for acyclovir ocular delivery: Formulation and cornea and sclera permeability

Cited by 71 publications

References 40 publications

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

Effect of melt extrudability and melt binding efficiency of polyvinyl caprolactam polyvinyl acetate polyethylene glycol graft copolymer (Soluplus®) on release pattern of hydrophilic and high dose drugs

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

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