2017
DOI: 10.1084/jem.20160844
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Zhong et al. describe two novel roles for soluble TREM2 (sTREM2) in regulation of proinflammatory responses and prevention of cellular apoptosis in microglia.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

13
228
1

Year Published

2017
2017
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 238 publications
(242 citation statements)
references
References 31 publications
13
228
1
Order By: Relevance
“…After demonstrating TREM2 involvement in cell proliferation and apoptosis, Zheng et al (2017) investigated the role of TREM2 in cell cycle progression and control. TREM2 KO resulted in an increased percentage of microglia in the G 1 /G 0 phase compared with WT microglial cells.…”
mentioning
confidence: 99%
See 3 more Smart Citations
“…After demonstrating TREM2 involvement in cell proliferation and apoptosis, Zheng et al (2017) investigated the role of TREM2 in cell cycle progression and control. TREM2 KO resulted in an increased percentage of microglia in the G 1 /G 0 phase compared with WT microglial cells.…”
mentioning
confidence: 99%
“…Because ␤-catenin initiates transcriptional activation of cyclin D1 and c-Myc, Zheng et al (2017) hypothesized that this protein might be a downstream effector of TREM2. First, they asked whether TREM2 regulates ␤-catenin transcription by measuring mRNA content.…”
mentioning
confidence: 99%
See 2 more Smart Citations
“…Additionally, the function of sTREM2 has not been elucidated, although elevated sTREM2 levels in CSF have been suggested to reflect microglial activation in response to neuronal degeneration [27][28][29][30][31]. In this respect, recent studies uncovered sTREM2 as not just an inactive end-product but also a signaling molecule [15] that promotes macrophage survival by preventing apoptosis [32] and activates microglia to ultimately trigger inflammatory responses and prolong survival [33]. These findings hint at the pathological implications of sTREM2 in chronic inflammation, and further elucidation of the pathophysiological roles of CSF and blood sTREM2 will provide significant novel clues on the regulation of central and systemic inflammation by targeting sTREM2 and/or sTREM2-related processes such as proteolytic production.…”
Section: Emerging Implications Of Trem2 and Strem2 In Neurodegeneratimentioning
confidence: 99%