Soluble Melanoma Cell Adhesion Molecule (sMCAM/sCD146) Promotes Angiogenic Effects on Endothelial Progenitor Cells through Angiomotin

CD133 + melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: Significance for melanoma treatment

“…Besides their ability to differentiate into various cell types [9], MSCs have the ability to form "melanoma spheroids" when grown in serum-free medium supplemented with growth factors [10], and exhibit self-renewal activity in vitro [1,11] and tumorigenic potency in vivo [12]. MSCs are also characterized by the expression of stem cell markers including CD20, CD133 [1,9,13], ABCB5 [14], CD166 [1,7], CD146 [15], and Nestin [16]. Also, the elevated expression of Bmi-1 has been reported in MSCs [17].…”

Soluble CD146, a new endothelial biomarker of acutely decompensated heart failure

“…Using the same approach, a second peptide was identified as of potential interest to discriminate International Journal of Cardiology 199 (2015) 241-247 ADHF patients from non-cardiac patients among those presenting with acute dyspnea, namely soluble CD146. CD146 is a component of the endothelial junction primarily expressed in endothelial cells and involved in the control of cell and tissue architecture [7], in cell signaling [8,9] and as more recently described in angiogenesis [10,11]. As CD146 belongs to a different physiological pathway than natriuretic peptides, we investigated if there was an added value of this marker in the context of acute heart failure.…”

Novel heart failure biomarkers: why do we fail to exploit their potential?

“…Mechanical disruption of endothelial junctions probably results in shedding of the long CD146 isoform (CD146-L) present on endothelial cells, which results in sCD146 that can be found in the circulation [146,148]. sCD146 promotes angiogenesis, but also seems to be a marker of endothelial damage, atherosclerosis, and plaque instability [149][150][151][152]. In patients with acutely decompensated HF, circulating sCD146 levels were increased and could aid in diagnosing acute HF in patients who were difficult to stratify based on NT-proBNP levels only (e.g.…”