volume 66, issue 9, P5183-5189 1992
DOI: 10.1128/jvi.66.9.5183-5189.1992
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Abstract: Herpes simplex virus type 1 (HSV-1) ocular infection in rats was blocked by treating the eyes with UVinactivated virions containing glycoprotein D (gD) prior to ocular challenge. In contrast, rats treated with UVinactivated virions lacking gD were not protected. A soluble, truncated form of HSV-2 gD (gD-2t) also protected against ocular infection. Treatment with gD-2t not only reduced mortality but also restricted progression of pathology and reduced the amount of viral antigen in the cornea. Host antibody or …

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