Soluble CXCL16 and risk of myocardial infarction: The HUNT study in Norway

Laugsand, Lars Erik; Åsvold, Bjørn Olav; Vatten, Lars J.; Janszky, Imre; Platou, Carl; Michelsen, Annika E.; Arain, Fizza; Damås, Jan Kristian; Aukrust, Pål; Ueland, Thor

doi:10.1016/j.atherosclerosis.2015.11.022

Cited by 18 publications

(23 citation statements)

References 34 publications

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“…Moreover, tissue CXCL16 expression has been found to be enhanced in inflammatory cardiomyopathy and to better predict mortality compared with other traditional cardiovascular risk factors in patients with heart failure who are undergoing endomyocardial biopsy [8]. The pathogenic role of CXCL16 in cardiovascular injury was further confirmed by Laugsand et al [9] who demonstrated that soluble CXCL16 was associated with the risk of myocardial infarction in a large general population without CVD. Notably, literature that offers contradictory findings has emerged and these findings favor an atheroprotective function of CXCL16 [10,11].…”

Section: Introductionsupporting

confidence: 48%

Interaction of Soluble CXC Ligand 16 and Cardiac Injury Markers in Hemodialysis Patients

Liu

Wang²,

Wei³

et al. 2017

Am J Nephrol

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Background: Recent data suggest that there is a pathogenic role for CXC ligand 16 (CXCL16) in cardiovascular diseases. Little is known about circulating CXCL16 in patients with kidney dysfunction. We explored the relationships of plasma CXCL16 with cardiac injury markers in a group of dialysis patients. Methods: Plasma CXCL16 and C-reactive protein (CRP) were measured in 366 patients who were on maintenance hemodialysis. Cardiac injury was evaluated via measurements of the circulating B-type natriuretic peptide (BNP), N-terminal prohormone of brain natriuretic peptide (NT proBNP), Troponin I (TnI), and Troponin T (TnT). Sixty healthy subjects who were frequency matched with the patients on the basis of age and gender were recruited as healthy controls. Results: The mean age of the patients was 52.5 ± 12.1 years and 56.3% were male. Circulating CXCL16 was significantly higher in the patients than in the controls (patients vs. controls: 477.3 (367.0-647.1) pg/mL vs. 229.5 (203.8-254.5) pg/mL; p < 0.001). The log-transformed (log-) CXCL16 level was correlated with all 4 cardiac markers (log-BNP, log-NTproBNP, log-TnI, and log-TnT) with high levels of significance (all p < 0.001), even after extensive controls for the covariates. In contrast, CRP was correlated only with BNP (marginally) and NT proBNP and was not correlated with troponins. Conclusion: We showed, for the first time, highly significant relationships of circulating CXCL16 level with cardiac injury markers in dialysis patients. Our data suggest that circulating CXCL16 is possibly involved in the pathological process of cardiovascular damage in dialysis patients and may serve as a therapeutic target for cardiac protection in these patients.

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Section: Introductionsupporting

confidence: 48%

Interaction of Soluble CXC Ligand 16 and Cardiac Injury Markers in Hemodialysis Patients

Liu

Wang²,

Wei³

et al. 2017

Am J Nephrol

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“…25 CXCL16 has furthermore been found to predict the risk of MI in healthy volunteers. 26 Accordingly, CXCL16 may be a new predictor of adverse outcome across the whole spectrum of CAD.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17][18][19][20] Several previous studies have found higher serum levels of CXCL16 in ACS versus stable CAD and controls. 17,[21][22][23] There are, however, only a few prospective studies investigating the use of CXCL16 as a risk marker in CAD 6,[24][25][26][27] , and only one of these included patients from an ACS population 6,24 .…”

Section: Introductionmentioning

confidence: 99%

C-X-C Ligand 16 Is an Independent Predictor of Cardiovascular Death and Morbidity in Acute Coronary Syndromes

Andersen

Ueland

Lakic

et al. 2019

ATVB

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Objective: The chemokine C-X-C motif ligand 16 (CXCL16) is a scavenger receptor for oxidized low-density lipoproteins and involved in inflammation at sites of atherosclerosis. This study aimed to investigate the association of CXCL16 with clinical outcome in patients with acute coronary syndrome (ACS). Approach and Results: Serial measurements of CXCL16 were performed in a subgroup of 5142 patients randomized in the PLATelet inhibition and patient Outcome (PLATO) trial. Associations between CXCL16 and a composite of cardiovascular (CV) death, spontaneous myocardial infarction (sMI) or stroke, and the individual components were assessed by multivariable Cox regression analyses. The hazard ratio (HR) per 50% increase in admission levels of CXCL16 analyzed as continuous variable was 1.64 (95% confidence interval [95%CI]: 1.44-1.88), p<0.0001. This association remained statistically significant after adjustment for randomized treatment, clinical variables, C-reactive protein, leukocytes, cystatin C, NT-proBNP, troponin T, Growth Differentiation Factor 15 and other biomarkers; HR 1.23 [1.05-1.45], p=0.0126. The admission level of CXCL16 was independently associated with CV death (1.50 [1.17-1.92], p=0.0014), but not with ischemic events alone, in fully adjusted analyses. No statistically independent association was found between CXCL16 measured at 1-month, or change in CXCL16 from admission to 1month, and clinical outcomes. Conclusions: In patients with ACS, admission level of CXCL16 is independently related to adverse clinical outcomes, mainly driven by an association to CV death. Thus, CXCL16 measurement may enhance risk stratification in patients with this condition.

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“…Some chemokines have been described as effective adipokines and as biomarkers of obese conditions because of their inflammatory profile, which is associated with weight gain and adipose tissue accumulation, and the fact that their receptors are overexpressed in subcutaneous and visceral adipose tissues of obese individuals [22]. Previous studies have indicated an association between CXCL16 and obesity in C57BL6 mice [23] and coronary comorbidities in humans [24–26]. By assuming that obesity predisposes individuals to coronary and metabolic diseases, the present study included overweight and obese women.…”

Section: Discussionmentioning

confidence: 99%

CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women

et al. 2017

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BackgroundThe current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because of the increasing number of overweight/obese cases worldwide. The aim of the present study was to assess CXCL16, IL-17, and BMP-2 plasma factors in middle-aged and elderly women and relate them to an overweight or obese status. In total, 117 women were selected and grouped as eutrophic, overweight, and obese, according to anthropometric parameters. Analyses of anthropometric and circulating biochemical parameters were followed by plasma immunoassays for CXCL-16, IL-17, and BMP-2.ResultsPlasma mediators increased in all overweight and obese individuals, with the exception of BMP-2 in the elderly group, whereas CXCL16 levels were shown to differentiate overweight and obese individuals. Overweight and/or obese middle-aged and elderly individuals presented with high LDL, triglycerides, and glycemia levels. Anthropometric parameters indicating increased-cardiovascular risk were positively correlated with CXCL-16, BMP-2, and IL-17 levels in overweight and obese middle-aged and elderly individuals.ConclusionThis study provides evidence that CXCL-16, IL-17, and BMP-2 are potential plasma indicators of inflammatory status in middle-aged and elderly women; therefore, further investigation of obesity-related comorbidities is recommended. CXCL16, in particular, could be a potential marker for middle-aged and elderly individuals transitioning from eutrophic to overweight body types, which represents an asymptomatic and dangerous condition.

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Soluble CXCL16 and risk of myocardial infarction: The HUNT study in Norway

Cited by 18 publications

References 34 publications

Interaction of Soluble CXC Ligand 16 and Cardiac Injury Markers in Hemodialysis Patients

Interaction of Soluble CXC Ligand 16 and Cardiac Injury Markers in Hemodialysis Patients

C-X-C Ligand 16 Is an Independent Predictor of Cardiovascular Death and Morbidity in Acute Coronary Syndromes

CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women

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