Solubilization of cyclodextrins for analytical applications

Pharr, Daniel Y.; Fu, Zheng; Smith, Thuy K.; Hinze, Willie L.

doi:10.1021/ac00178a018

Cited by 87 publications

(26 citation statements)

References 48 publications

(34 reference statements)

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“…Although CDs are considered to be fairly stable under basic conditions, 19 some researchers observed the coloration of aqueous CD solution and intensification of the color with time, even under dilute NaOH concentration ($1.0 M). 20 Their observation suggests a possible partial decomposition of CDs by residual alkali molecules, which may lead to release of linear glucose oligomers and resulting increase in DD values in our case.…”

Section: Resultsmentioning

confidence: 61%

Effect of preparation conditions for poly(ethylene glycol)/cyclodextrin polyrotaxane on modes of end‐capping reactions and decomposition of the yielded polyrotaxane

Araki

2010

J. Polym. Sci. A Polym. Chem.

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Section: Resultsmentioning

confidence: 61%

Effect of preparation conditions for poly(ethylene glycol)/cyclodextrin polyrotaxane on modes of end‐capping reactions and decomposition of the yielded polyrotaxane

Araki

2010

J. Polym. Sci. A Polym. Chem.

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“…The solubility of the native cyclodextrins depends strongly on the number of glucopyranoses [42,43] and may be increased by addition of either alcohols [43] or another organic solvent miscible with water [44] or urea [45]. However, the competition of the additives with the analytes for the cyclodextrin affects the separation [46] since cyclodextrins have a general capability to host any compound.…”

Section: Cyclodextrinsmentioning

confidence: 99%

Chiral separations in capillary electrophoresis

Vespalec

Boček

1999

Electrophoresis

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published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User

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“…Since our analytes possess one to three aromatic rings we chose/3-CD as the most appropriate one for these molecular sizes [44]. The low water solubility of/3-CD restricts its concentration to 16 mmol L -1 at maximum [44,46]. It is not recommended to apply cyclodextrins in combination with borate buffers since a polyol-borate complex will be formed and buffer absorption is increased around 200 nm [47].…”

Section: Fl-cyclodextrinmentioning

confidence: 99%

Separation of 18 modern plant protectants using cyclodextrin modified micellar electrokinetic chromatography including an ion-pairing reagent

Stutz

Malissa

1998

Mikrochim Acta

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Abstract.A cyclodextrin-modified micellar electrokinetic chromatography separation for 18 different pesticides (metsuifuron-methyl, rimsulfuron, thifensulfuron-methyl, desethylatrazine, desisopropylatrazine, atrazine, simazine, terbuthylazine, 2,4-D, MCPR MCPB, dicamba, linuron, alachlor, metolachlor, orbencarb, propiconazole, prochloraz) from eight different substance classes with very varying chemical and physical properties is presented. In particular acidbase characteristics and water-octanol distribution coefficients diverge in wide ranges. 3-cyclodextrin was successfully employed as a modifier in separating the hydrophobic analytes. Peak distortion of some neutral analytes, which is devoted to the methanol content of the sample zone, was reduced by increasing the SDS concentration. Methanol in the sample is necessary for a better solubility of the hydrophobic pesticides. Few optima of SDS concentration exist allowing the separation of sulfonylureas as well as phenoxy acids and hydrophobic pesticides. An improved resolution of the sulfonylureas was achieved with tetramethylammonium chloride, which was used as an ion-pairing reagent.' Final operating conditions for the separation of all these plant protectant compounds by MEKC in just one single run are a 27mmolL -1 phosphate buffer, pH 8.03, with 95mmolL-1SDS, 5rmnolL =1 /3-cyclodextrin and 10 mmolL -1 tetramethylammonium-chloride.Key words: capillary electrophoresis, micellar electrokinetic chromatography, multi-residue-analysis, pesticide analysis. * To whom correspondence should be addressedThe relevance of high performance capillary electrophoresis (HPCE) applied in multi-residue methods for trace analysis of plant protectants in environmental samples has attained growing interest in the past few years. With a few exceptions authors restrict themselves to one class of pesticides, such as triazines [1-3], hydroxy-or methoxymetabolites of triazines, either alone or in combination with their parent compounds [4][5][6][7], phenoxy acids [8-11 ], phenylurea-[12], sutfonylurea-[13, 14J or dipyridylium-pesticides [15,16]. The application of capillary zone electrophoresis (CZE) dominates over micellar electrokinetic chromatography (MEKC). For neutral analytes or more complex pesticide mixtures MEKC is selected [17][18][19][20][21][22]. HPCE is more versatile than HPLC and GC since there is nearly no restriction to certain pesticide classes and therefore derivatization becomes unnecessary. Within the HPCE-techniques MEKC is more likely to separate complex substance mixtures than CZE, which is restricted to charged substances. This is due to various surfactants and modifiers that can be selected and combined in MEKC to optimize separation.In the field of multi-residue separation several successful attempts are published which show the general viability of MEKC technique. These approaches, however, were confined to mixtures of hydrophilic and moderately hydrophobic pesticides [18,21] including one hydrophobic pesticide at maximum [22]. If more than one hydrophobic ...

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Solubilization of cyclodextrins for analytical applications

Cited by 87 publications

References 48 publications

Effect of preparation conditions for poly(ethylene glycol)/cyclodextrin polyrotaxane on modes of end‐capping reactions and decomposition of the yielded polyrotaxane

Effect of preparation conditions for poly(ethylene glycol)/cyclodextrin polyrotaxane on modes of end‐capping reactions and decomposition of the yielded polyrotaxane

Chiral separations in capillary electrophoresis

Separation of 18 modern plant protectants using cyclodextrin modified micellar electrokinetic chromatography including an ion-pairing reagent

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