Solubilization and thermodynamic properties of simvastatin in various micellar solutions of different non-ionic surfactants: Computational modeling and solubilization capacity

Abstract

The aim of this work was to solubilize simvastatin (SIM) using different micellar solutions of various non-ionic surfactants such as Tween-80 (T80), Tween-20 (T20), Myrj-52 (M52), Myrj-59 (M59), Brij-35 (B35) and Brij-58 (B58). The solubility of SIM in water (H2O) and different micellar concentrations of T80, T20, M52, M59, B35 and B58 was determined at temperatures T = 300.2 K to 320.2 K under atmospheric pressure p = 0.1 MPa using saturation shake flask method. The experimental solubility data of SIM was regressed using van’t Hoff and Apelblat models. The solubility of SIM (mole fraction) was recorded highest in M59 (1.54 x 10−2) followed by M52 (6.56 x 10−3), B58 (5.52 x 10−3), B35 (3.97 x 10−3), T80 (1.68 x 10−3), T20 (1.16 x 10−3) [the concentration of surfactants was 20 mM in H2O in all cases] and H2O (1.94 x 10−6) at T = 320.2 K. The same results were also recorded at each temperature and each micellar concentration of T80, T20, M52, M59, B35 and B58. “Apparent thermodynamic analysis” showed endothermic and entropy-driven dissolution/solubilization of SIM in H2O and various micellar solutions of T80, T20, M52, M59, B35 and B58.

Assembly of nanostructured lipid carriers loaded gefitinib and simvastatin as hybrid therapy for metastatic breast cancer: Codelivery and repurposing approach

“…GFT and SIM concentration in all samples was measured using the Dionex™ ultrahigh‐performance liquid chromatography (UHPLC) system through the previously developed two methods (Shakeel et al, 2021; Sherif et al, 2023b). Regarding GFT, the used mobile phase was comprised of 40:60:0.1 (v/v/v) acetonitrile: water: trimethylamine, and phosphoric acid was used to adjust pH to 6.7.…”

Determination of Solubility and Thermodynamic Analysis of Iron(III) β-Diketonate Compounds in Pure Solvents

“…An essential subject of research for the equilibrium of solute–solvent and solute–solute interactions is the solid–liquid phase equilibrium theory . Solubility data is one of the essential parameters of solid–liquid phase equilibrium theory and serves as the foundation for practical procedures such as compound synthesis, separation, and participation in reactions. − Solubility is the mass of the solute that can be dissolved when a solution is saturated at a given temperature. By measuring the solubility data of compounds in different solvents, it is possible to facilitate the study of drug synthesis, pharmacokinetic properties, and clinical applications, , as well as homogeneous catalytic reaction rates and equilibria, among others. , Crystallization separation is a prevalent separation operation, which occupies an important position with the advantages of greenness, low energy consumption, and higher product purity.…”

Developing Nanosuspension Loaded with Azelastine for Potential Nasal Drug Delivery: Determination of Proinflammatory Interleukin IL-4 mRNA Expression and Industrial Scale-Up Strategy

“…Additionally, AZN is sparingly soluble in methanol and propylene glycol and only marginally soluble in ethanol, octanol, and glycerine (log P is 2.3) . AZN has 40% systemic bioavailability (BA) after intranasal delivery, reaching peak plasma concentration ( C max ) after 2–3 h. One of the most significant issues with drug research is the inability of some pharmaceuticals to dissolve in water. − For insoluble drugs, excipients such as surfactants, cosolvents, micellar solutions, complexing agents, and lipid formulations are required to increase their solubility. − Unfortunately, the need for more materials to create weakly water-soluble compounds may increase the risk of negative outcomes. To increase the solubility and BA of medications that are poorly water-soluble, a number of strategies have been developed, including solid dispersion, complexation, lipid-based systems, micronization, nanonization, and cocrystals. − Nanotechnology-based medication delivery can get around some anatomical, physiological, pharmacological, and clinical problems with traditional dose forms in all of these technologies .…”