volume 267, issue 1-2, P121-127 2003
DOI: 10.1016/j.ijpharm.2003.08.006
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Abstract: The results obtained previously by Ruckenstein and Shulgin [Int. J. Pharm. 258 (2003a) 193; Int. J. Pharm. 260 (2003b) 283] via the fluctuation theory of solutions regarding the solubility of drugs in binary aqueous mixed solvents were extended in the present paper to multicomponent aqueous solvents. The multicomponent mixed solvent was considered to behave as an ideal solution and the solubility of the drug was assumed small enough to satisfy the infinite dilution approximation. An expression derived for the …

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