ABSTRACT. The solubility of Ilaprazole in methanol, ethanol, 2-propanol and n-butanol was measured using a gravimetrical method at temperature ranging from 298.15 K to 322.15 K. The results of these measurements were correlated with a semi empirical equation. Some thermodynamic parameters such as dissolution enthalpy, Gibb's free energy, and entropy of mixing have also been calculated.