Solitary Bone and Extramedullary Plasmacytoma

Salogub, Galina; Lokhmatova, Ekaterina; Sozin, Sergey

doi:10.5772/30651

Cited by 2 publications

(3 citation statements)

References 71 publications

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“… 12 Other sites of EMP include the digestive tract, skin, lung, breast, eye socket, retroperitoneal area, and testicle. 9 In the present study, the vertebral column and upper respiratory tract were found to be the most common site of SBP and EMP, accounting for 28.9% and 38.1% of cases, respectively. So the common sites of occurrence of SBP and EMP in the present study were basically similar to those reported in previous studies.…”

Section: Discussionsupporting

confidence: 48%

“…According to the current literature, 9 skeletal survey to confirm solitary bone lesion, bone marrow biopsy to ensure plasma cell percentage, biopsy to prove plasma cell infiltration, and relative laboratory examinations to exclude myeloma-related organ dysfunction are all necessary for the diagnosis of SP. Patients were enrolled in the present study in accordance with these requirements.…”

Section: Discussionmentioning

confidence: 99%

“…5 − 7 The EMP cases were selected on the basis of the recommended diagnostic criteria, including single extramedullary masses of clonal plasma cells; histologically normal marrow aspirate and trephine samples; normal skeletal survey results, including radiology of the long bones; no anemia, hypercalcemia, or renal impairment attributable to plasma cell dyscrasia; and little or no serum or urinary monoclonal immunoglobulin. 7 − 9 …”

Section: Methodsmentioning

confidence: 99%

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Prognostic factors associated with solitary plasmacytoma

Guo¹,

Zhang²,

Wang³

et al. 2013

OTT

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Solitary plasmacytoma (SP) is a rare tumor with low incidence. The aim of this study was to investigate the clinical features, treatment strategies, and relative prognostic factors of 66 patients with SP. These patients made up 10.25% of the 644 patients with plasma cell dyscrasias treated at the Tianjin Medical University Cancer Institute and Hospital over the past 12 years. SP always presented with either solitary bone plasmacytoma (SBP) or extramedullary plasmacytoma (EMP), as determined by the location of the lesions. SBP occurred most frequently in the vertebral column and EMP in the upper respiratory tract. In addition to other factors, tumor size, serum M protein level, urinary Bence Jones protein level, and disease progression toward multiple myeloma were significantly different between the two groups (P,0.05). Larger tumor size ($5 cm) was associated with poor prognosis of local control, multiple myelomafree survival, overall survival and progression-free survival for SBP patients. Radiotherapy and serum β 2 microglobulin ,3.5 mg/L were favorable prognostic factors for local control, multiple myeloma-free survival, and progression-free survival in patients with EMP.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%