Solids Go Bio: Inorganic Nanoparticles as Enzyme Mimics

Ragg, Ruben; Tahir, M.N.; Tremel, Wolfgang

doi:10.1002/ejic.201600408

Cited by 13 publications

(12 citation statements)

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“…Since the first evidence of ferromagnetic nanoparticles as peroxidase mimetics was reported in 2007 1 , various nanomaterials have been identified that possess intrinsic enzyme-like activities 2 – 6 . These materials catalyze enzymatic reactions and follow similar enzymatic kinetics and mechanisms of natural enzymes under physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

et al. 2018

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Nanomaterials with intrinsic enzyme-like activities (nanozymes), have been widely used as artificial enzymes in biomedicine. However, how to control their in vivo performance in a target cell is still challenging. Here we report a strategy to coordinate nanozymes to target tumor cells and selectively perform their activity to destruct tumors. We develop a nanozyme using nitrogen-doped porous carbon nanospheres which possess four enzyme-like activities (oxidase, peroxidase, catalase and superoxide dismutase) responsible for reactive oxygen species regulation. We then introduce ferritin to guide nitrogen-doped porous carbon nanospheres into lysosomes and boost reactive oxygen species generation in a tumor-specific manner, resulting in significant tumor regression in human tumor xenograft mice models. Together, our study provides evidence that nitrogen-doped porous carbon nanospheres are powerful nanozymes capable of regulating intracellular reactive oxygen species, and ferritinylation is a promising strategy to render nanozymes to target tumor cells for in vivo tumor catalytic therapy.

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Section: Introductionmentioning

confidence: 99%

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

et al. 2018

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“…Bacterial species shows selectivity for particular nanoparticles. Silver nanoparticles shows antibacterial activity efficiently than copper nanoparticles aganist E. coli and S. aureus, while B. subtilis shows more susceptibility to copper nanoparticles than silver nanoparticles [34]. Nanoparticles of titanium dioxide shows greater antibacterial activity against E. coli than S. typhimurium.…”

Section: Introductionmentioning

confidence: 95%

Antibacterial activity of LaNiO3 prepared by sonicated sol-gel method using combination fuel

Jadhav

Khetre

2019

Int Nano Lett

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Sonicated sol-gel method was used to prepare LaNiO 3 from lanthanum nitrate hexahydrate La(NO 3) 3 .6H 2 O(LN), nickel nitrate Ni(NO 3) 3 .6H 2 O(NN), glycine and urea. Nanocrystalline LaNiO 3 powder was formed after heating at 175 °C in 5 min. Particle size of LaNiO 3 nanopowder was determined by Debay Scherrer's equation and was found 48 nm. Prepared nanocatalyst characterized with the help of XRD, TGA, SEM, IR, BET surface area, EDX. Surface area of LaNiO 3 was 9.22 m 2 /g. We have reported first time good antibacterial activity of LaNiO 3 for Staphylococcus aureus. Zone of inhibition for LaNiO 3 was 13 mm studied with the help of agar cup method.

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“…[27] Other excellent in-depth reviews on the nanozyme concept and broad applications are available elsewhere. [6, 14, 28, 29] Here, we focus on emerging biomedical applications of catalytic nanomaterials, and their progress towards clinical use based on recent findings using in vivo models.…”

Section: Intrinsic Enzyme-like Properties Of Nanomaterialsmentioning

confidence: 99%

Emerging Biomedical Applications of Enzyme-Like Catalytic Nanomaterials

Cormode

Gao

Koo

2018

Trends in Biotechnology

167

101

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Nanomaterials have been developed for many biomedical applications, including medical imaging, drug delivery, and antimicrobial coatings. Intriguingly, nanoparticles can display 'enzyme-like' activity and have been explored as alternatives to natural enzymes in several industrial and energy-related applications. Recently, these catalytic nanomaterials with enzyme-mimetic properties have found new biomedical applications, from biofilm disruption to protection against neurodegeneration and tumor prevention. In this review we focus on recent in vivo studies demonstrating potential therapeutic uses of catalytic nanomaterials. We also provide insights about the relationships between catalytic activity, therapeutic efficacy, and biocompatibility that are critical for clinical translatability. Finally, we discuss current challenges and future directions for the use of these nanomaterials as novel platforms for the development of sustainable, affordable, and safe therapeutics.

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Solids Go Bio: Inorganic Nanoparticles as Enzyme Mimics

Abstract: The cover image shows inorganic nanoparticles that mimic the catalytic activity of naturally occurring enzymes. The nanoparticles are more stable and cost-efficient, and their high surface area endows them with a large number of active sites.

Cited by 13 publications

References 0 publications

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy

Antibacterial activity of LaNiO3 prepared by sonicated sol-gel method using combination fuel

Emerging Biomedical Applications of Enzyme-Like Catalytic Nanomaterials

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