Solid‐Phase Synthesis and Combinatorial Technologies

Solid‐Phase Synthesis of Oligo(phenylene ethynylene) Rotaxanes

“…[1] This strategy has been exploited to synthesize p-conjugated oligomers for optoelectronic applications, such as oligo(phenylene ethynylene)s (OPEs), [2][3][4] oligothiophenes, [5,6] and oligo(phenylene triacetylene)s. [7] Solid-phase synthesis is also a promising strategy for the synthesis of monodisperse oligomeric "insulated molecular wires". [8] Recently we have developed the synthesis of polyrotaxane-type insulated molecular wires by threading cyclodextrin (CD) macrocycles onto a conjugated polymer chain to achieve supramolecular control of the chemical stability, photoluminescence, and electroluminescence efficiency.…”

A Novel, One-Step Palladium and Phenylsilane Activated Amidation from Allyl Ester on Solid Support

“…The carboxylic acid functional group has been widely used in solid-phase chemistry, especially when protected as an ester. An allyl ester is a commonly used protecting group that can be used with many acid or base-labile linkers, and is removed easily with Pd(PPh 3 ) 4 in various solvent systems with the aid of a scavenger reagent [1][2][3]. Phenylsilane, acting as a hydride donor, has been reported to be an excellent scavenger when used in conjunction with Pd(PPh 3 ) 4 in the removal of the allyl ester group [4].…”

Application of the Suzuki‐Miyaura cross‐coupling reaction for the modification of phenylalanine peptides

“…The application of combinatorial chemistry is a powerful tool in peptidomimetic design. [45][46][47][48][49][50][51][52][53][54][55][56] Therefore, utilization of these building blocks in combinatorial fashion can quickly deliver various peptide analogues. Motivated by such a need for post-translational peptide modification strategies suitable for combinatorial chemistry research, we proposed various synthetic methodologies to generate unusual peptides by post-translational peptide modifications.…”