Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro

Tang, Jingling; Ji, Hongyu; Ren, Jinmei; Li, Mengting; Zheng, Nannan; Lin-hua, WU

doi:10.3892/ol.2016.5421

Cited by 50 publications

(23 citation statements)

References 31 publications

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“…Higher fluorescence intensity of CurcuEmulsomes in the presence of PiperineEmulsomes was attributed to occurrence of a higher uptake. These findings is parallel to the previous studies reporting that the extent of curcumin uptake is improved significantly by piperine addition (Gülseren et al, 2014;Tang et al, 2017). Likewise, Lund and Pantuso demonstrated that addition of piperine resulted in a 229% increase in permeability of curcumin across intact Caco-2 monolayers (Lund and Pantuso, 2014).…”

Section: Cellular Uptakesupporting

confidence: 86%

“…While its presence as the second drug agent reduced the cell viability, no inhibition of cell proliferation was observed for piperine or PiperineEmulsome alone within the concentration range tested. This behavior was previously reported by Tang et al (2017) on drug-resistant human ovarian A2780/Taxol cells (Tang et al, 2017). While high concentrations are required for piperine to show its anticancer effect alone, when co-delivered with curcumin, low concentrations of piperine are sufficient to contribute curcumin's anti-cancer effect (Shoba et al, 1998).…”

Section: Cell Viabilitysupporting

confidence: 70%

“…Behaving synergistically, the second agent enhances the curcumin's anti-cancer activity. Doxorubicin (Zhao et al, 2015;Lv et al, 2016;Dash and Konkimalla, 2017a); docetaxel (Bayet-Robert et al, 2010;Yan et al, 2016); gemcitabine (Dhillon et al, 2008;Epelbaum et al, 2010;Kanai et al, 2011), celebrex (Lev-Ari et al, 2005;Abdallah et al, 2018), paclitaxel (Ganta and Amiji, 2009;Boztas et al, 2013;Abouzeid et al, 2014;Sarisozen et al, 2014;Kim et al, 2016;Yang et al, 2017;Calaf et al, 2018), campthotecin (Xiao et al, 2015), cisplatin (Li et al, 2017), resveratrol (Du et al, 2013), epigallocatechin gallate (EGCG) (Vivar-Quintana et al, 2006;Jin et al, 2017), sulforaphane (Danafar et al, 2018) and piperine (Shaikh et al, 2009;Kakarala et al, 2010;Patial et al, 2015;Vecchione et al, 2016;Tang et al, 2017;Baspinar et al, 2018) are among the active molecules studied in combination with curcumin for their synergistic anticancer behavior.…”

Section: Introductionmentioning

confidence: 99%

“…Among the proposed secondary agents, piperine, a dietary polyphenol isolated from black and long peppers, distinguished with its intrinsic features, does not only improve curcumin's existing anti-cancer activity, but also its extremely poor bioavailability (Teiten et al, 2010;Patial et al, 2015;Tang et al, 2017). Besides, piperine alone possesses anti-mutagenic and antitumor influences (Srinivasan, 2007;Chinta et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model

Bolat

İşlek

Demir

et al. 2020

Front. Bioeng. Biotechnol.

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Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates a collaborative action. Curcumin, isolated from turmeric, and piperine, isolated from black long pepper, are two dietary polyphenols studied for their intrinsic anti-cancer properties against various cancer types including colorectal cancer (CRC). Furthermore, piperine improves the therapeutic effect of curcumin. Addressing this mutual behavior, this study combines curcumin and piperine within emulsome nanoformulations. Curcumin-(CurcuEmulsomes) and piperine-loaded emulsomes (PiperineEmulsomes) have established a uniform, stable, spherical dispersion with average diameters of 184.21 and 248.76 nm, respectively. The solid tripalmitin inner core achieved encapsulation capacities of up to 0.10 mg/ml curcumin and 0.09 mg/ml piperine content. While piperine treatment alone-in its both free and emulsome forms-showed no inhibition in the proliferation of HCT116 cells in vitro, its presence as the second drug agent enhanced curcumin's effect. Combination of 7 µM PiperineEmulsome and 25 µM CurcuEmulsome concentrations was found to be most effective with an inhibition of cell proliferation of about 50% viability. Cell cycle arrest at G2/M phase and induced apoptosis verified the improved anti-cancer characteristics of the therapy. While CurcuEmulsomes achieved a fourfold increase in Caspase 3 level, combination of treatment with PiperineEulsomes achieved a sixfold increase in the level of this apoptotic marker. Combinational treatment of HCT116 cells with CurcuEmulsomes and PiperineEmulsomes improved the anticancer activity of the compounds and highlighted the potential of the approach for further in vivo studies.

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Section: Cellular Uptakesupporting

confidence: 86%

Section: Cell Viabilitysupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model

Bolat

İşlek

Demir

et al. 2020

Front. Bioeng. Biotechnol.

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“…SLN were found to be effective in, in-vitro studies of reversing P-glycoprotein-mediated multidrug resistance in A2780/Taxol cells. Curcumin SLN selectively killed tumor cells with low intrinsic toxicity 50 . The bioavailability of solid lipid nanoparticles can be increased by surface modification with N-carboxymethyl chitosan(NCC).…”

Section: Sln In Cancermentioning

confidence: 99%

Solid lipid nanoparticles: a promising technology for delivery of poorly water-soluble drugs

Bhatt¹,

Sharma²,

Singh³

et al. 2018

actapharm

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Oral administration of drugs having low water solubility is hampered by various enzymatic barriers present in gastrointestinal (GI) tract. Lipid nanoparticles based on solid matrix have emerged as a potential drug delivery system to improve the absorption and bioavailability of several drugs, especially lipophilic compounds. Solid lipid nanoparticles (SLN) are reported as the most promising technology for oral administration and offered several advantages over conventional dosages formulations including, enhancement in solubility, stability, permeability, and bioavailability with minimal side effects. In this review, we have highlighted recent advances in the development of SLN for the oral, parenteral, rectal, and topical administration of various drugs. We have also summarized the applications of SLN in the treatment of various diseases like tuberculosis, cancer, diabetes, and several nervous system related disorders. sustained release, timed release, extended release, and targeted release of a drug. The predominance of nanoparticles over the other drug delivery systems enables them to use for drug targeting. Nanoparticles are 10-100nm in size in which drug is either dispersed or entrapped in a matrix, encapsulated as the solid solution or may be adsorbed on the surface 2 .The nanoparticles are designed to provide intimate contact with GI epithelium, prolong residence time and allow permeation across the cell membrane. A pre-systemic metabolism of a drug can be avoided by using nanoparticles 3 . Lipid nanoparticles are safe to use as they contain lipids, which are included in the category of generally recognized as safe (GRAS). Solid Lipid NanoparticlesSolid lipid nanoparticles are an advanced and rapidly budding field of nanotechnology with several applications in pharmaceutical science. SLN were developed first in 1991. These are the colloidal carriers possesses an average diameter of 10 to 1000nm. They composed of single lipid core matrix dispersed in an aqueous surfactant solution. The carriers like liposomes, polymeric micelles, and porous solids can also be used to enhance the aqueous solubility of a drug. But SLN not only helps to increase the solubility of a drug but also offers target release of drugs. SLN can be used as a carrier for lipophilic as well as hydrophilic drugs 4 . SLN provides stability to the solid lipid matrix and overcomes the disadvantages of liposomes, which includes stability problems 5 . Instead of polymeric nanoparticles, SLN are found to be more compatible with the biological system. Exclusive properties of SLN such as smaller size, larger surface area and interaction of phases at the interface make them valuable candidate 2 . The release of encapsulated compounds is controlled by solid lipid matrix, which also improves the stability of incorporated lipophilic ingredients. The type of lipids, surfactants and their concentration in the formulation of SLN adjust the particle size, drug loading, and release behavior of drugs 5 . The physicochemical characteristics of the solid lipid...

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Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets

Ghobadi

Asoodeh

2023

Phytotherapy Research

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Natural plant phytochemicals are effective against different types of diseases, including cancer. Curcumin, a powerful herbal polyphenol, exerts inhibitory effects on cancer cell proliferation, angiogenesis, invasion, and metastasis through interaction with different molecular targets. However, the clinical use of curcumin is limited due to poor solubility in water and metabolism in the liver and intestine. The synergistic effects of curcumin with some phytochemicals such as resveratrol, quercetin, epigallocatechin-3-gallate, and piperine can improve its clinical efficacy in cancer treatment. The present review specifically focuses on anticancer mechanisms related to the co-administration of curcumin with other phytochemicals, including resveratrol, quercetin, epigallocatechin-3-gallate, and piperine. According to the molecular evidence, the phytochemical combinations exert synergistic effects on suppressing cell proliferation, reducing cellular invasion, and inducing apoptosis and cell cycle arrest. This review also emphasizes the significance of the co-delivery vehicles-based nanoparticles of such bioactive phytochemicals that could improve their bioavailability and reduce their systemic dose. Further highquality studies are needed to firmly establish the clinical efficacy of the phytochemical combinations.

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Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro

Cited by 50 publications

References 31 publications

Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model

Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model

Solid lipid nanoparticles: a promising technology for delivery of poorly water-soluble drugs

Co‐administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets

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