Archives of Dermatology
 1977
DOI: 10.1001/archderm.113.9.1222
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Solar urticaria treatment by inducing tolerance to artificial radiation and natural light

Colin A. Ramsay1

Abstract: Solar urticaria was treated by means of repeated exposures of the skin to fluorescent lamps or natural sunlight. Repeated exposures over a period of hours induce a state of tolerance in the skin so that urticaria fails to develop. The state of tolerance can be maintained with regular daily exposures, and treatment can lead to complete symptomatic relief. Determination of the action spectrum for urticaria is advisable in order to choose the correct fluorescent lamp for treatment.

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Cited by 38 publications

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“…The mechanism of the tolerance induced by UVA hardening in SU is unknown. The conventional wisdom is that repeated exposure causes degranulation of the mast cells and keeps these cells depleted of mediators 9,11,13 . However, in our cases, the responses to histamine and to compound 48/80, a nonspecific inducer of mast cell degranulation, were unaltered at several months after hardening compared with the responses before hardening.…”
Section: Discussion
contrasting
confidence: 50%
“…These two patients with serum factor‐positive SU benefited greatly from UVA rush hardening, as documented by marked increases in the MWD, including visible light as well as UVA, in a short time. Patient 1 became tolerant within 4 months and has remained symptom free for over 12 months without treatment, although such tolerance was quickly lost without continual treatments in most cases 9 . This therapy was not associated with any significant side‐effects.…”
Section: Discussion
mentioning
confidence: 94%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The mechanism of the tolerance induced by UVA hardening in SU is unknown. The conventional wisdom is that repeated exposure causes degranulation of the mast cells and keeps these cells depleted of mediators 9,11,13 . However, in our cases, the responses to histamine and to compound 48/80, a nonspecific inducer of mast cell degranulation, were unaltered at several months after hardening compared with the responses before hardening.…”
Section: Discussion
contrasting
confidence: 50%
“…These two patients with serum factor‐positive SU benefited greatly from UVA rush hardening, as documented by marked increases in the MWD, including visible light as well as UVA, in a short time. Patient 1 became tolerant within 4 months and has remained symptom free for over 12 months without treatment, although such tolerance was quickly lost without continual treatments in most cases 9 . This therapy was not associated with any significant side‐effects.…”
Section: Discussion
mentioning
confidence: 94%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Interestingly, some CIndUs can be treated by desensitization to triggers. This phenomenon has been described for cold urticaria , heat urticaria , and solar urticaria . Although CIndU can present with a very chronic course (Table ), with rare exceptions, CIndU patients experience spontaneous remission.…”
Section: General Recommendations For the Management Of Cindus
mentioning
confidence: 75%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Another therapeutic option would be desensitization, which is indicated only for cold urticaria, (22,23) heat contact urticaria, (24) and solar urticaria. (25) Nonetheless, this induction of tolerance is not long lasting, and daily exposure to the triggering stimulus is necessary. In our study, no patient was submitted to desensitization protocols.…”
Section: ❚ Results
mentioning
confidence: 99%
“…(26) Additionally, two studies have shown that chronic urticaria seriously compromises the quality of life of patients, due to the debilitating symptoms, which can last for years. (23,25) In one of the studies, 59.8% of patients needed ongoing treatment with AH1. (10) A Brazilian review article mentioned that physical weals are skin conditions resulting from the presence of mastocyte with decreased threshold for degranulation, induced by environmental physical triggering factors, whether located or diffuse, classic or atypical, acquired or familial, with or without the participation of IgE, with variable durations, that can worsen with stress and disappear spontaneously.…”
Section: ❚ Results
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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