Solar urticaria. Determinations of action and inhibition spectra

Hasei, Kazuyoshi

doi:10.1001/archderm.118.5.346

Cited by 32 publications

(39 citation statements)

References 3 publications

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“…IS were first reported by Hasei and Ichihashi [1]and have been found mainly in Japanese patients with solar urticaria [2]. The IS observed in our cases displayed unique characteristics, that is, it prevented wheal formation during IS irradiation and wheals developed after cessation of the irradiation.…”

Section: Introductionmentioning

confidence: 50%

Solar Urticaria: A Consideration of the Mechanism of Inhibition Spectra

Watanabe¹,

Matsunaga²,

Katayama³

1999

Dermatology

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Background: Solar urticaria is a rare disorder characterized by pruritus, erythema and wheal upon sunlight exposure. Inhibition spectra (IS), which prevent wheal formation, have been found mainly in Japanese patients and lie mostly in longer wavelengths than the action spectrum (AS). The exact mechanism of AS and IS has not been clarified. Patients and Methods: To elucidate the mechanism of AS and IS, we conducted photobiological studies including in vitro irradiated serum injection tests and measurements of plasma histamine levels in 3 patients with IS. Results: All patients had AS ranging between 400 and 490 nm and IS ranging between 520 and 610 nm. A wheal reaction appeared soon after the termination of IS irradiation. The patients developed no wheal or erythema upon intradermal injection of preirradiated serum. Plasma histamine levels were not elevated during irradiation with slide projector light, but marked elevation of histamine was observed when wheals developed after the termination of inhibitory irradiation. Conclusion: These results suggest that the IS in our cases might inactivate photoallergens produced by AS and, additionally, stabilize mast cell degranulation.

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Section: Introductionmentioning

confidence: 50%

Solar Urticaria: A Consideration of the Mechanism of Inhibition Spectra

Watanabe¹,

Matsunaga²,

Katayama³

1999

Dermatology

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“…An inhibition spectrum was first demonstrated in solar urticaria by Hasei and Ichihashi [3], who observed that the irradiation by longer wavelengths than the action spectrum, immediately after the exposure to urticaria-eliciting light, inhibited the development of urticaria. This phenomenon is not uncommon [8] and has been confirmed by other inves tigators [9 -11], On the other hand, the augmentation spec trum has been demonstrated so far in only 1 patient which was reported by Horio and Fujigaki [4J.…”

Section: Discussionmentioning

confidence: 98%

“…A patient who showed a marked broadening of the action spectrum was also documented by Murphy and Hawk |2). In addition, the inhibition [3] and augmentation spectra [4] were also found to be present in certain cases of solar urticaria. Consequently, various wave-lengths seem to affect the reaction of solar urticaria in com plicated interactions.…”

Section: Introductionmentioning

confidence: 93%

Detection of Action, Inhibition and Augmentation Spectra in Solar Urticaria

Miyauchi

Horio²

1995

Dermatology

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Background: The action spectrum of solar urticaria varies among cases. In addition, light spectra outside the activating wavelengths can influence the wheal formation in selected patients. Objective: To know the mechanisms of light energy, we examined the effect of wavelengths on the skin and the serum factor. Methods: The patient’s skin and serum were exposed to artificial light sources, in vivo and in vitro, respectively. Results: The action spectrum ranged from UVA to visible light (∼480 nm). The exposure to longer wavelengths immediately after the exposure inhibited the development of urticaria. Conversely, the irradiation of longer wavelengths before exposure increased the wheal formation. Furthermore, UVB irradiation prior to the exposure of urticaria-eliciting light also increased the urticarial reaction, while postirradiation of UVB had no effect. The patient developed an urticarial wheal at the site of injection of her own serum, which had been previously exposed to the action spectrum in vitro. Preirradiation increased the production of the photosensitizer, while postirradiation revealed no effect. Ultrafiltration techniques showed that the molecular weight of the photosensitizer is more than 300 kD. Conclusion: We detected action, inhibition and augmentation spectra in a patient with a severe solar urticaria. Various wavelengths influence the wheal-forming factor in complex interactions.

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“…Recently, a case of solar ur ticaria with inhibition spectrum was report ed [3], and wealing in the patient was com pletely inhibited by exposure to visible light above 690 nm. We also encountered a simi lar patient showing an inhibition spectrum in the red light range (visible light longer than 660 nm).…”

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confidence: 99%

Solar Urticaria Inhibited by Visible Light

1983

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A 25-year-old man with solar urticaria is described. The action spectrum ranged from 400 to 500 nm. An inhibition spectrum was found to be in the visible light range above 660 nm. Simultaneous or alternate exposure to ‘blue-violet light’ and ‘red light’ mostly inhibited weal formation. The urticarial reaction was not blocked by local injection of antihistamines and not prevented by histamine depletion with polymyxin B sulfate. These data suggest that histamine may not play a major role in weal production in this case.

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Solar urticaria. Determinations of action and inhibition spectra

Cited by 32 publications

References 3 publications

Solar Urticaria: A Consideration of the Mechanism of Inhibition Spectra

Solar Urticaria: A Consideration of the Mechanism of Inhibition Spectra

Detection of Action, Inhibition and Augmentation Spectra in Solar Urticaria

Solar Urticaria Inhibited by Visible Light

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