Sol–gel derived hydroxyapatite/titania biocoatings on titanium substrate

Xu, Wei; Hu, Wangyu; Li, Meiheng; Wen, Cuié

doi:10.1016/j.matlet.2005.11.072

Cited by 69 publications

(35 citation statements)

References 17 publications

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“…Coating metallic implants with bioactive materials, like HA, may accelerate bone formation during initial stages of osseointegration and thereby improving implant fixation www.intechopen.com (Vidigal et al, 1999). Thin HA film on titanium substrates can be prepared using sol-gel (Xu et al, 2006) or electrophoresis techniques (Wang et al, 2002). The sol-gel and electrophoresis methods are capable of improving chemical homogeneity in the resulting HA coating to a significant extent, when compared to conventional methods such as solid state reactions, wet precipitation and hydrothermal synthesis (Milev et al, 2003).…”

Section: Sol-gel Coated Implantsmentioning

confidence: 99%

Dental Implant Surface Enhancement and Osseointegration

Anil¹,

Anand²,

Alghamdi³

et al. 2011

Implant Dentistry - A Rapidly Evolving Practice

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Section: Sol-gel Coated Implantsmentioning

confidence: 99%

Dental Implant Surface Enhancement and Osseointegration

Anil¹,

Anand²,

Alghamdi³

et al. 2011

Implant Dentistry - A Rapidly Evolving Practice

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“…They can be generally divided in two main groups: solid-state reactions and wet processes. The solid-state reactions include precipitation, hydrothermal technique and hydrolysis of other calcium phosphates (Mobasherpour et al 2007), while the wet route concerns mainly the sol-gel process (Pereira et al 2005;Xu et al 2006). Depending upon the route and technique used, HA bioceramics with various morphology, Ca/P ratios, microstructure and level of crystallinity can be obtained.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of a new composite biomaterial fluor-hydroxyapatite on fibroblast cell line NIH-3T3 by direct test

et al. 2008

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The number of biomaterials used in biomedical applications has rapidly increased in the past two decades. Fluorapatite (FA) is one of the inorganic constituents of bone or teeth used for hard tissue repairs and replacements. Fluor-hydroxyapatite (FHA) is a new synthetically prepared composite that in its structure contains the same molecular concentration of OH − groups and F − ions. The aim of this experimental investigation was to use the embryonal mouse fibroblast cell line NIH-3T3 for comparative study of basal cytotoxicity of fluoridated biomaterials FHA and FA discs. Hydroxyapatite (HA) disc, high-density polyethylene as negative control and polyvinyl chloride (PVC) containing organotin stabilizer as positive control were used as standard biomaterials. The appropriateness of the use of NIH-3T3 cells and their sensitivity for tested biomaterials were evaluated on the basis of five cytotoxic end points: cell proliferation, cell morphology, lactate dehydrogenase (LDH) released, protein and DNA cell content. The basal cytotoxicity of FHA, FA and HA discs was measured by direct contact method. FHA composite, FA and HA demonstrated in cell line NIH-3T3 nearly similar basal cytotoxicity increasing with the time of treatment. After 72 h of biomaterials treatment, about 25% inhibition of cell number, unchanged morphology of dividing cells, 6.31-0.16% increase of released LDH, about 10% inhibition of cell protein content and about 20% inhibition of DNA content was found. On the other hand, from the growth rates it resulted that NIH-3T3 cells, affected by tested biomaterials, divided about 20% slowlier than the control (untreated cells). Using the linear regression analysis we found out that deviations in measurements of cytotoxicity by four methods were as follows: less than 10% for cell number, protein and DNA content methods and 12.4% for released LDH method. Based on a good correlation of the cytotoxicity of biomaterials obtained from all end points we could conclude that fibroblast NIH-3T3 cell line was appropriate for measuring the basal cytoxicity of tested biomaterials.

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“…Synthetic HA-bioceramics are obtained by different chemical and technical processes [13][14][15][16]. They can be generally divided in two main groups: solid-state reactions and wet processes.…”

Section: Introductionmentioning

confidence: 99%

“…They can be generally divided in two main groups: solid-state reactions and wet processes. The solid-state reactions include precipitation, hydrothermal technique and hydrolysis of other calcium phosphates [14], while the wet route mainly involves the sol-gel process [15,16]. Depending upon the route and technique used, HA bioceramics with various morphology, Ca/P ratios, microstructure and level of crystallinity can be obtained.…”

Section: Introductionmentioning

confidence: 99%