SOHO State of the Art Updates and Next Questions | Optimal Timing of Blinatumomab for the Treatment of B-Acute Lymphoblastic Leukemia

Pinchinat, Ashley; Gupta, Sumit; Cooper, Stacy; Rau, Rachel E.

doi:10.1016/j.clml.2022.12.011

Clinical Lymphoma Myeloma and Leukemia

2023

DOI: 10.1016/j.clml.2022.12.011

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SOHO State of the Art Updates and Next Questions | Optimal Timing of Blinatumomab for the Treatment of B-Acute Lymphoblastic Leukemia

Ashley Pinchinat¹,

Sumit Gupta²,

Stacy Cooper³

et al.

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2024

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Changing the location of proteins on the cell surface is a promising strategy for modulating T cell functions

Strazza,

Song,

Hiner

et al. 2024

Immunology

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Targeting immune receptors on T cells is a common strategy to treat cancer and autoimmunity. Frequently, this is accomplished through monoclonal antibodies targeting the ligand binding sites of stimulatory or inhibitory co‐receptors. Blocking ligand binding prevents downstream signalling and modulates specific T cell functions. Since 1985, the FDA has approved over 100 monoclonal antibodies against immune receptors. This therapeutic approach significantly improved the care of patients with numerous immune‐related conditions; however, many patients are unresponsive, and some develop immune‐related adverse events. One reason for that is the lack of consideration for the localization of these receptors on the cell surface of the immune cells in the context of the immune synapse. In addition to blocking ligand binding, changing the location of these receptors on the cell surface within the different compartments of the immunological synapse could serve as an alternative, efficient, and safer approach to treating these patients. This review discusses the potential therapeutic advantages of altering proteins' localization within the immune synapse and summarizes published work in this field. It also discusses the novel use of bispecific antibodies to induce the clustering of receptors on the cell surface. It presents the rationale for developing novel antibodies, targeting the organization of signalling receptor complexes on the cell surface. This approach offers an innovative and emerging technology to treat cancer patients resistant to current immunotherapies.

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Changing the location of proteins on the cell surface is a promising strategy for modulating T cell functions

Strazza,

Song,

Hiner

et al. 2024

Immunology

View full text Add to dashboard Cite

show abstract

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SOHO State of the Art Updates and Next Questions | Optimal Timing of Blinatumomab for the Treatment of B-Acute Lymphoblastic Leukemia

Cited by 1 publication

References 61 publications

Changing the location of proteins on the cell surface is a promising strategy for modulating T cell functions

Changing the location of proteins on the cell surface is a promising strategy for modulating T cell functions

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