Software‐guided Microfluidic Reaction Calorimeter Based on Thermoelectric Modules

Abstract

A software‐guided, continuous reaction calorimeter based on thermoelectric modules for direct heat flux measurements is presented. Sensors and actuators of the calorimeter's setup are implemented within a lab automation system, which enables the automated calibration of the heat flux sensors and investigations of chemical reactions through sequential function charts. Functionality of the calibration is shown by heat transfer experiments. Additionally, the calorimeter's performance is demonstrated by good agreement of conducted neutralization experiments with literature data.

Design and characterization of a flow reaction calorimeter based on FlowPlate® Lab and Peltier elements

“…Based on experience with microscale flow reaction calorimeters using commercially available microreactors in our research group, [20][21][22]30 the calorimeter concept was integrated into the FlowPlate® Lab Version 1 microreactor system from Ehrfeld Mikrotechnik in its "stand-alone" version. The different FlowPlate® modules have been widely utilized and characterized in the literature.…”

“…10 Concerning calorimetry using microreactors, three basic concepts prevail for technical realization: optical measurements using infrared cameras, [11][12][13][14][15] energy balance based on temperature measurements, 9,16 and heat flux measurements using the thermoelectric effect. [17][18][19][20][21][22][23][24][25][26] Although several flow calorimeters have been developed using these concepts or combinations of them, only a few are commercially available. An example for a commercially available flow calorimeter is provided by Fluitec, Neftenbach, Switzerland.…”

Advances in Continuous Flow Calorimetry

“…Calibration of the Seebeck elements was carried out with a heating cartridge, which was implemented into a brass block matching the Seebeck element's base area. In the following work by Frede et al, 53 both the calibration procedure and the overall modular setup of the calorimeter were automated. The neutralization reactions of acetic acid, sulfuric acid, and hydrochloric acid with sodium hydroxide were investigated.…”

Reactor performance estimation in microscale flow calorimeter for rapid characterization of exothermic reactions

“…A commercially available microreactor from Little Things Factory GmbH (Elsoff, Germany) is investigated in the simulations. The LTF-MS reactor from the MR-Lab series is studied in this work, which is the scale-up version of the LTF type-S reactor, which was employed in the microcalorimeter in previous works [14,15,27]. A schematic representation of reactor is shown in Fig.…”

“…Continuous flow calorimetry enables to estimate reaction conversion from the heat released. Especially, spatially resolved reaction calorimetry, as developed by several groups [10][11][12][13][14][15][16][17][18], allows to follow the reaction progress along the reaction channel and enables thermokinetic characterization of chemical processes. Despite the recording of spatially resolved heat flux profiles, the calorimetric measurement data were often only used for an energy balance of the system to determine the enthalpy of reaction.…”