Soft Tissue Sarcomas

Liptak, Julius M.; Christensen, Neil

doi:10.1016/b978-0-323-59496-7.00022-0

Cited by 31 publications

(53 citation statements)

References 198 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tumors of the skin and subcutaneous tissues are common in dogs, with malignant tumors comprising 20-40% of skin masses submitted for histopathology [51]. Soft tissue sarcomas (STS) arise from the connective tissues, comprising 15% of all skin tumors in dogs, and are subclassified pathologically based on the tissue of origin [52]. Common tumor types seen in clinical practice include fibrosarcoma, perivascular wall tumor, peripheral nerve sheath tumor, liposarcoma, and myxosarcoma.…”

Section: Veterinary Clinical Oncology Patient Populations For Histotripsy Developmentmentioning

confidence: 99%

Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review

Hendricks-Wenger

Arnold

Gannon

et al. 2022

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

New therapeutic strategies are direly needed in the fight against cancer. Over the last decade, several tumor ablation strategies have emerged as stand-alone or combination therapies. Histotripsy is the first completely non-invasive, non-thermal, and non-ionizing tumor ablation method. Histotripsy can produce consistent and rapid ablations, even near critical structures. Additional benefits include real-time image-guidance, high precision, and the ability to treat tumors of any predetermined size and shape. Unfortunately, the lack of clinically and physiologically relevant pre-clinical cancer models is often a significant limitation with all focal tumor ablation strategies. The majority of studies testing histotripsy for cancer treatment have focused on small animal models, which have been critical in moving this field forward and will continue to be essential for providing mechanistic insight. While these small animal models have notable translational value, there are significant limitations in terms of scale and anatomical relevance. To address these limitations, a diverse range of large animal models and spontaneous tumor studies in veterinary patients have emerged to complement existing rodent models. These models and veterinary patients are excellent at providing realistic avenues for developing and testing histotripsy devices and techniques designed for future use in human patients. Here, we provide a review of animal models used in preclinical histotripsy studies and compare histotripsy ablation in these models using a series of original case reports across a broad spectrum of preclinical animal models and spontaneous tumors in veterinary patients.

show abstract

Section: Veterinary Clinical Oncology Patient Populations For Histotripsy Developmentmentioning

confidence: 99%

Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review

Hendricks-Wenger

Arnold

Gannon

et al. 2022

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

show abstract

“…Cytology of the mass revealed the presence of atypical mesenchymal cells. Cytology obtained from soft tissue sarcomas (STS) can be non-diagnostic due to poor exfoliation of cells or presence of necrosis resulting in a reported 63 to 97% accuracy in diagnosis ( 13 – 15 ). Given this, biopsy is recommended to obtain a definitive diagnosis, as well as histological grade ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

“…Cytology obtained from soft tissue sarcomas (STS) can be non-diagnostic due to poor exfoliation of cells or presence of necrosis resulting in a reported 63 to 97% accuracy in diagnosis ( 13 – 15 ). Given this, biopsy is recommended to obtain a definitive diagnosis, as well as histological grade ( 13 ). In this case, histopathology was most consistent with a fibrosarcoma for the mediastinal mass.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Mediastinal Fibrosarcoma in a Dog–Case Report

et al. 2022

View full text Add to dashboard Cite

This represents the first published case report of mediastinal fibrosarcoma in a dog. An 8-year-old male neutered mixed breed dog was presented for evaluation of lethargy and increased panting. Thoracic focused assessment with sonography for trauma revealed moderate pleural effusion. Thoracic radiograph findings were suggestive of a cranial mediastinal mass. Computed tomography revealed a mass within the right ventral aspect of the cranial mediastinum. On surgical exploration, a cranial mediastinal mass with an adhesion to the right cranial lung lobe was identified and removed en-bloc using a vessel sealant device and requiring a partial lung lobectomy. Histopathology results described the cranial mediastinal mass as fibrosarcoma with reactive mesothelial cells identified within the sternal lymph node. The patient was treated with systemic chemotherapy following surgical removal. To date, the dog has survived 223 days following diagnosis with recurrence noted 161 days following diagnosis and radiation therapy was initiated. Primary cranial mediastinal fibrosarcoma while a seemingly rare cause of thoracic pathology in dogs, should be considered in the differential diagnosis for a cranial mediastinal mass.

show abstract

“…Although a larger cellular specimen is expected from smooth muscle tumors as compared to other mesenchymal tumors, preoperative cytology was diagnostic in only 2 out of the 10 cases which underwent the procedure, likely due to the poor tendency of these tumors to exfoliate, [ 8 ]. However, given the low invasiveness of the procedure, FNA cytology should always also be performed to exclude the diagnosis of readily exfoliating malignant tumors, such as epithelial and round cell tumors [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Benign or Low-Grade Malignant Masses Occupying the Pelvic Canal Space in 11 Dogs

Ferraris

Giacobino

Iussich

et al. 2021

Animals

View full text Add to dashboard Cite

Dogs with benign intra-pelvic rectal or vaginal masses show symptoms indicating compression on the adjacent organs. Clinical signs usually develop late when the lesion is large enough to interfere functionally. The dogs were referred for severe fecal and/or urinary tenesmus. The data collected included signalment, clinical signs, results of physical examination, pre-surgical diagnostic tests, surgical technique used, surgical complications and histological findings. Digital rectal and vaginal examination allowed the detection of a mass occupying space in the pelvic cavity in all patients. Abdominal ultrasonography and/or total body computed tomography (CT) were used to better characterize the lesion and to exclude a metastatic spread of the tumor in case of malignancy. A dorsal approach to the rectum, a dorsal episiotomy, a midline celiotomy, and a combined perineal and abdominal approach were performed to remove the mass. No postoperative complications were observed. Benign and well-differentiated malignant mesenchymal neoplasms were histologically diagnosed. As a consequence of the chronic urethral compression caused by the mass, urinary incontinence and/or urinary retention were observed for a few postoperative days. Fecal tenesmus resolved in all cases in the immediate postoperative period. The dogs’ quality of life quickly improved after surgery, especially considering the serious and life-threatening pre-surgical clinical conditions. Both the recovery time after surgery and overall survival were also evaluated.

show abstract

Soft Tissue Sarcomas

Cited by 31 publications

References 198 publications

Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review

Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review

Mediastinal Fibrosarcoma in a Dog–Case Report

Benign or Low-Grade Malignant Masses Occupying the Pelvic Canal Space in 11 Dogs

Contact Info

Product

Resources

About