Soft contact lenses functionalized with pendant cyclodextrins for controlled drug delivery

Santos, Jose-Fernando Rosa dos; Alvarez‐Lorenzo, Carmen; Silva, Maite; Balsa, Luis; Couceiro, José; Torres-Labandeira, Juan-Jose; Concheiro, Ángel

doi:10.1016/j.biomaterials.2008.11.016

Cited by 149 publications

(53 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Medicated contact lenses (CL) are attracting escalating interest because of their ability to prolong the residence time of drugs on the precorneal area, increasing the ocular bioavailability and diminishing loss by blinking and unproductive systemic absorption [5]. …”

Section: Introductionmentioning

confidence: 99%

Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study

Curcio

Cirillo

Parisi

et al. 2011

JFB

View full text Add to dashboard Cite

A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an estimation of the amount of quercetin bound per gram of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows high biocompatibility (HET-CAM assay) and antioxidant and anti-inflammatory properties which were extensively investigated by specific in vitro tests.

show abstract

Section: Introductionmentioning

confidence: 99%

Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study

Curcio

Cirillo

Parisi

et al. 2011

JFB

View full text Add to dashboard Cite

show abstract

“…A different approach consists of designing synthetic networks with domains capable of mimicking the recognition features of the biological macromolecules. Various semisynthetic ringtype substances, such as crown ethers, cryptates, cyclophanes, or cyclodextrins, can host in their cavity certain molecules forming inclusion complexes [49][50][51][52][53]. The selectivity of the interactions with these materials is conditioned by the size of the cavities and the arrangement of their chemical groups.…”

Section: Molecule-responsive and Imprinted Systemsmentioning

confidence: 99%

Nanostructures and Nanostructured Networks for Smart Drug Delivery

Álvarez-Lorenzo

Puga

2012

Biomimetic Approaches for Biomaterials Development

Self Cite

View full text Add to dashboard Cite

“…[31, 32] However, the plasma conditions have to be carefully controlled as insufficient and aggressive treatments either do not have any effect or have the potential to result in the loss of the drugs' bioactivity. Recently contact lenses have been combined with nano-/micro- scale drug delivery systems such as liposomes,[33] polymeric materials,[15, 27, 30, 34] and micelles[35]. These nano-/micro- scale drug delivery systems offer high drug loading capacity and suitability for nearly any kind of drug by rational design of the system.…”

Section: Introductionmentioning

confidence: 99%

Development of ciprofloxacin-loaded contact lenses using fluorous chemistry

et al. 2017

View full text Add to dashboard Cite

In this work, we developed a simple method to load drugs into commercially available contact lenses utilizing fluorous chemistry. We demonstrated this method using model compounds including fluorous-tagged fluorescein and antibiotic ciprofloxacin. We showed that fluorous interactions facilitated the loading of model molecules into fluorocarbon-containing contact lenses, and that the release profiles exhibited sustained release. Contact lenses loaded with fluorous-tagged ciprofloxacin exhibited antimicrobial activity against Pseudomonas aeruginosa in vitro, while no cytotoxicity towards human corneal epithelial cells was observed. To mimic the tear turnover, we designed a porcine eye infection model under flow conditions. Significantly, the modified lenses also exhibited antimicrobial efficacy against Pseudomonas aeruginosa in the ex vivo infection model. Overall, utilizing fluorous chemistry, we can construct a drug delivery system that exhibits high drug loading capacity, sustained drug release, and robust biological activity.

show abstract

Soft contact lenses functionalized with pendant cyclodextrins for controlled drug delivery

Cited by 149 publications

References 47 publications

Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study

Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study

Nanostructures and Nanostructured Networks for Smart Drug Delivery

Development of ciprofloxacin-loaded contact lenses using fluorous chemistry

Contact Info

Product

Resources

About