Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review

Abstract

Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review.

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“…The number and duration of EP attacks were effectively suppressed, suggesting that valproate sodium in combination with carbamazepine significantly affects treating EP. Similarly, this is consistent with the results of previous studies (Nevitt et al, 2018a, Pino et al, 2021, which can corroborate the results of the current experiment. It is well known that sodium valproate is a nitrogen-free broad-spectrum antiepileptic drug and one of the common drugs used in clinical practice for the treatment of EP and that the drug is mainly distributed in the extracellular fluid and mostly bound to plasma proteins in the blood (Li et al, 2019).…”

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“…The number and duration of EP attacks were effectively suppressed, suggesting that valproate sodium in combination with carbamazepine significantly affects treating EP. Similarly, this is consistent with the results of previous studies (Nevitt et al, 2018a, Pino et al, 2021, which can corroborate the results of the current experiment. It is well known that sodium valproate is a nitrogen-free broad-spectrum antiepileptic drug and one of the common drugs used in clinical practice for the treatment of EP and that the drug is mainly distributed in the extracellular fluid and mostly bound to plasma proteins in the blood (Li et al, 2019).…”

Weight-centric treatment of depression and chronic pain

“…Phenytoin is an anticonvulsant that blocks voltage-dependent membrane sodium channels [ 146 ]. Phenytoin has been reported to be weight neutral in several studies and reviews [ 19 , 147 , 148 ]. Chen et al.…”

“… NSAIDs All ? TCAs All X X [ 164 ] SNRIs All X [ 67 ] Anticonvulsants Gabapentin X [ 165 ] Pregabalin X [] Carbamazepine X [] Phenytoin X [ 166 ] Topiramate X [ 167 ] Title: The effect of different medications for chronic pain on body weight. X: <5% of total body weight change.…”

Valproate encephalopathy: Case series and literature review

“… 25 , 26 In turn, sodium valproate may affect the metabolism of PHT thus affecting its concentration in the body, leading to PHT poisoning. 25 On the other hand, sodium valproate may increase the total plasma concentration of PHT as well as the concentration of free PHT, which may trigger symptoms of overdose. 1 , 20 Carbamazepine belongs to the substrate of the CYP enzyme, and when sodium valproate is used in combination with carbamazepine, it may inhibit the activity of these enzymes, thereby slowing the drug metabolism of carbamazepine, increasing the plasma concentration of these drugs and increasing the risk of toxicity.…”

“…24 PHT is a liver enzyme inducer, and it can increase liver glucosylation and the activity of the liver microsomal somatotrope P450 system, which will increase the metabolism of sodium valproate in the liver. 25,26 In turn, sodium valproate may affect the metabolism of PHT thus affecting its concentration in the body, leading to PHT poisoning. 25 On the other hand, sodium valproate may increase the total plasma concentration of PHT as well as the concentration of free PHT, which may trigger symptoms of overdose.…”

Untitled

“…The number and duration of EP attacks were effectively suppressed, suggesting that valproate sodium in combination with carbamazepine significantly affects treating EP. Similarly, this is consistent with the results of previous studies (Nevitt et al, 2018a, Pino et al, 2021, which can corroborate the results of the current experiment. It is well known that sodium valproate is a nitrogen-free broad-spectrum antiepileptic drug and one of the common drugs used in clinical practice for the treatment of EP and that the drug is mainly distributed in the extracellular fluid and mostly bound to plasma proteins in the blood (Li et al, 2019).…”

Weight-centric treatment of depression and chronic pain

“…Phenytoin is an anticonvulsant that blocks voltage-dependent membrane sodium channels [ 146 ]. Phenytoin has been reported to be weight neutral in several studies and reviews [ 19 , 147 , 148 ]. Chen et al.…”

“… NSAIDs All ? TCAs All X X [ 164 ] SNRIs All X [ 67 ] Anticonvulsants Gabapentin X [ 165 ] Pregabalin X [] Carbamazepine X [] Phenytoin X [ 166 ] Topiramate X [ 167 ] Title: The effect of different medications for chronic pain on body weight. X: <5% of total body weight change.…”

Valproate encephalopathy: Case series and literature review

“… 25 , 26 In turn, sodium valproate may affect the metabolism of PHT thus affecting its concentration in the body, leading to PHT poisoning. 25 On the other hand, sodium valproate may increase the total plasma concentration of PHT as well as the concentration of free PHT, which may trigger symptoms of overdose. 1 , 20 Carbamazepine belongs to the substrate of the CYP enzyme, and when sodium valproate is used in combination with carbamazepine, it may inhibit the activity of these enzymes, thereby slowing the drug metabolism of carbamazepine, increasing the plasma concentration of these drugs and increasing the risk of toxicity.…”

“…24 PHT is a liver enzyme inducer, and it can increase liver glucosylation and the activity of the liver microsomal somatotrope P450 system, which will increase the metabolism of sodium valproate in the liver. 25,26 In turn, sodium valproate may affect the metabolism of PHT thus affecting its concentration in the body, leading to PHT poisoning. 25 On the other hand, sodium valproate may increase the total plasma concentration of PHT as well as the concentration of free PHT, which may trigger symptoms of overdose.…”

Untitled

“…The number and duration of EP attacks were effectively suppressed, suggesting that valproate sodium in combination with carbamazepine significantly affects treating EP. Similarly, this is consistent with the results of previous studies (Nevitt et al, 2018a, Pino et al, 2021, which can corroborate the results of the current experiment. It is well known that sodium valproate is a nitrogen-free broad-spectrum antiepileptic drug and one of the common drugs used in clinical practice for the treatment of EP and that the drug is mainly distributed in the extracellular fluid and mostly bound to plasma proteins in the blood (Li et al, 2019).…”

Weight-centric treatment of depression and chronic pain

“…Phenytoin is an anticonvulsant that blocks voltage-dependent membrane sodium channels [ 146 ]. Phenytoin has been reported to be weight neutral in several studies and reviews [ 19 , 147 , 148 ]. Chen et al.…”

“… NSAIDs All ? TCAs All X X [ 164 ] SNRIs All X [ 67 ] Anticonvulsants Gabapentin X [ 165 ] Pregabalin X [] Carbamazepine X [] Phenytoin X [ 166 ] Topiramate X [ 167 ] Title: The effect of different medications for chronic pain on body weight. X: <5% of total body weight change.…”

Valproate encephalopathy: Case series and literature review

“… 25 , 26 In turn, sodium valproate may affect the metabolism of PHT thus affecting its concentration in the body, leading to PHT poisoning. 25 On the other hand, sodium valproate may increase the total plasma concentration of PHT as well as the concentration of free PHT, which may trigger symptoms of overdose. 1 , 20 Carbamazepine belongs to the substrate of the CYP enzyme, and when sodium valproate is used in combination with carbamazepine, it may inhibit the activity of these enzymes, thereby slowing the drug metabolism of carbamazepine, increasing the plasma concentration of these drugs and increasing the risk of toxicity.…”

“…24 PHT is a liver enzyme inducer, and it can increase liver glucosylation and the activity of the liver microsomal somatotrope P450 system, which will increase the metabolism of sodium valproate in the liver. 25,26 In turn, sodium valproate may affect the metabolism of PHT thus affecting its concentration in the body, leading to PHT poisoning. 25 On the other hand, sodium valproate may increase the total plasma concentration of PHT as well as the concentration of free PHT, which may trigger symptoms of overdose.…”