Sodium Sulfathiazole Iontophoresis

The Role of Iontophoresis in Ocular Drug Delivery

“…Seech and LeGrande Cooper (17) studied the histological corneal changes incurred as a result of iontophoresis of different electrolyte solutions, and reported two cases of corneal dystrophy successfully treated with transcorneal iontophoresis of quinine bisulfate. Boyd (18) noted that the corneal and aqueous concentrations of sodium sulfathiazole after transcorneal iontophoresis in rabbits using a current of 1 mA for 2 minutes were markedly greater than concentrations obtained using a corneal bath. Fleming (19) discussed the various clinical cases in which he had successfully used iontophoresis, including the treatment of acute conjunctivitis, herpes zoster ophthalmicus, scleritis, and retrobulbar neuritis.…”

The Role of Iontophoresis in Ocular Drug Delivery

“…Seech and LeGrande Cooper (17) studied the histological corneal changes incurred as a result of iontophoresis of different electrolyte solutions, and reported two cases of corneal dystrophy successfully treated with transcorneal iontophoresis of quinine bisulfate. Boyd (18) noted that the corneal and aqueous concentrations of sodium sulfathiazole after transcorneal iontophoresis in rabbits using a current of 1 mA for 2 minutes were markedly greater than concentrations obtained using a corneal bath. Fleming (19) discussed the various clinical cases in which he had successfully used iontophoresis, including the treatment of acute conjunctivitis, herpes zoster ophthalmicus, scleritis, and retrobulbar neuritis.…”

Present Status of Physiotherapy in Ocular Disease

“…Quinine, salicylate, and other therapeutic agents have been similarly employed (Erlanger, 1936;Selinger, 1947;Morisot, 1947). In prolonged bacteriostatic concentrations the sulpha derivatives, especially sulphadiazine and sulphacetamide, have been shown to enter the anterior chamber thus in up to ten times their normal concentration after simple diffusion (Boyd, 1942;Sallmann, 1942). Penicillin is less amenable to ionic transference; some authorities claim success with it, either alone or in combination with sulphathiazole (Sallmann, 1944), but Bauwens and Paterson (1951) have shown experimentally that it loses its efficacy when introduced through the cornea in this way.…”

The Role of Iontophoresis in Ocular Drug Delivery

“…Seech and LeGrande Cooper (17) studied the histological corneal changes incurred as a result of iontophoresis of different electrolyte solutions, and reported two cases of corneal dystrophy successfully treated with transcorneal iontophoresis of quinine bisulfate. Boyd (18) noted that the corneal and aqueous concentrations of sodium sulfathiazole after transcorneal iontophoresis in rabbits using a current of 1 mA for 2 minutes were markedly greater than concentrations obtained using a corneal bath. Fleming (19) discussed the various clinical cases in which he had successfully used iontophoresis, including the treatment of acute conjunctivitis, herpes zoster ophthalmicus, scleritis, and retrobulbar neuritis.…”

Present Status of Physiotherapy in Ocular Disease

“…Quinine, salicylate, and other therapeutic agents have been similarly employed (Erlanger, 1936;Selinger, 1947;Morisot, 1947). In prolonged bacteriostatic concentrations the sulpha derivatives, especially sulphadiazine and sulphacetamide, have been shown to enter the anterior chamber thus in up to ten times their normal concentration after simple diffusion (Boyd, 1942;Sallmann, 1942). Penicillin is less amenable to ionic transference; some authorities claim success with it, either alone or in combination with sulphathiazole (Sallmann, 1944), but Bauwens and Paterson (1951) have shown experimentally that it loses its efficacy when introduced through the cornea in this way.…”

The Role of Iontophoresis in Ocular Drug Delivery

“…Seech and LeGrande Cooper (17) studied the histological corneal changes incurred as a result of iontophoresis of different electrolyte solutions, and reported two cases of corneal dystrophy successfully treated with transcorneal iontophoresis of quinine bisulfate. Boyd (18) noted that the corneal and aqueous concentrations of sodium sulfathiazole after transcorneal iontophoresis in rabbits using a current of 1 mA for 2 minutes were markedly greater than concentrations obtained using a corneal bath. Fleming (19) discussed the various clinical cases in which he had successfully used iontophoresis, including the treatment of acute conjunctivitis, herpes zoster ophthalmicus, scleritis, and retrobulbar neuritis.…”

Present Status of Physiotherapy in Ocular Disease

“…Quinine, salicylate, and other therapeutic agents have been similarly employed (Erlanger, 1936;Selinger, 1947;Morisot, 1947). In prolonged bacteriostatic concentrations the sulpha derivatives, especially sulphadiazine and sulphacetamide, have been shown to enter the anterior chamber thus in up to ten times their normal concentration after simple diffusion (Boyd, 1942;Sallmann, 1942). Penicillin is less amenable to ionic transference; some authorities claim success with it, either alone or in combination with sulphathiazole (Sallmann, 1944), but Bauwens and Paterson (1951) have shown experimentally that it loses its efficacy when introduced through the cornea in this way.…”