Sodium potassium dependent ATPase in hypophysectomized rats: Response to growth hormone, triiodothyronine, and cortisone

Shimomura, Yuichi; Lee, M.; Oku, J.; Bray, George A.; Glick, Z.

doi:10.1016/0026-0495(82)90055-5

Cited by 36 publications

(22 citation statements)

References 16 publications

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“…This effect of GH was demonstrated already early in the 1950s [32] and was later shown to be independent of aldosterone [33]. In vitro studies support the hypothesis that the antinatri uretic action of GH is a tubular effect and that GH acts by increasing the sodium pump activity [34,35], In acro megalic patients, we have found an inverse relationship between GH concentration before surgery (GH concen tration >20m U /l) and the erythrocyte sodium efflux rate constant. After successful adenomectomy (GH con centration < 5 mU/1), however, there was a positive rela tionship between GH concentrations and erythrocyte sodium efflux rate constant.…”

Section: Effects Of Gh On Body Compositionsupporting

confidence: 67%

Growth Hormone and Body Composition

Bengtsson¹,

Brummer²,

Bosæus³

1990

Horm Res

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Through its anabolic, lipolytic and antinatriuretic actions, GH has profound effects on body composition. In untreated acromegaly, body weight, body cell mass and extracellular water are increased simultaneously with a decrease of body fat. After successful treatment, extracellular water and body fat normalize, but cell mass remains high. The changes in cell mass, body fat and extracellular water observed in acromegaly suggest different dose-response relationships between GH and these parameters. The relationship between GH concentration and the lipolytic actions of GH is more linear, while the relationship between GH and excess extracellular water is more curvilinear. The sodium-retaining effect of GH seems to be mediated by stimulation of the Na⁺-K⁺ pump. At higher GH levels, the pump activity is counteracted by an alleged sodium transport inhibitor. In GH-deficient children, GH treatment is followed by rapid loss of adipose tissue and muscular gain. The influence of GH on body composition in GH-deficient adults has recently received attention. Compared to normal subjects, these patients are overweight and have decreased cell mass. Replacement treatment with GH restores body composition towards normal.

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Section: Effects Of Gh On Body Compositionsupporting

confidence: 67%

Growth Hormone and Body Composition

Bengtsson¹,

Brummer²,

Bosæus³

1990

Horm Res

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“…Many investigators have reported that an increase in extracellular fluid and retention of Na exist in acromegaly [7][8][9][10][11][12][13][14][15], and these were thought to contribute to hypertension. In addition, the increase in extracellular fluid was reduced after treatment of the disease [9].…”

Section: Discussionmentioning

confidence: 99%

“…These findings suggest that hypertension in acromegaly is produced by increased Na and not through the renin-aldosterone system. In this regard, it was suggested that increased activity of the Na pump and the presence of a digitalis-like factor in acromegaly contribute to this anti-natriuretic action of GH [11,15,23]. And it was suggested that this action is to be independent of aldosterone [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

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Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Ohtsuka

Komiya²,

Aizawa

et al. 1995

Endocr J

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Abstract.Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension.The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium (Na) concentration.In addition, IGF-I and Na were significantly different in hypertensive and normotensive groups. Seventy-five percent of hypertensive patients had a family history of hypertension.IGF-I, Na and blood pressure were significantly higher in patients with a family history of hypertension than in those without it. In patients with a family history of hypertension, blood pressure was positively correlated with IGF-I and serum Na, but IGF-I was not correlated with serum Na. In patients without such a family history, blood pressure had a good correlation only with age, and IGF-I was not significantly correlated with blood pressure. In addition, the incidence of hypertension in this group was the same as or lower than that in the general population.The above results suggest that the genetic factor produces hypertension in acromegaly by two ways, by increasing Na and enhancing IGF-I production by GH.

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“…Two different theories have been proposed in the literature to explain the role of GH/IGF1 system in renal re-absorption regulation and water homeostasis. In rats and human liver, brain and kidney, exposure to Renal structure and function in acromegaly GH (22,23) has been shown to increase the activity of Na-K-ATPase, which is mainly responsible for the transepithelial NaCl re-absorption. Recent studies (24,25) have demonstrated in rats that the acute administration of rGH induces the phosphorylationmediated activation of the kidney-specific Na, K, and Cl co-transporter.…”

Section: Controlled Patients (B)mentioning

confidence: 99%

The kidney in acromegaly: renal structure and function in patients with acromegaly during active disease and 1 year after disease remission

Auriemma

Galdiero

Martino

et al. 2010

European Journal of Endocrinology

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Background: The GH/insulin-like growth factor 1 axis is physiologically involved in the regulation of electrolytes and water homeostasis by kidneys, and influences glomerular filtration and tubular re-absorption processes. The aim of the study was to investigate renal structure and function in acromegalic patients during active disease and disease remission. Patients: Thirty acromegalic patients (15 males and 15 females), aged 32-70 years, were enrolled for the study. Ten de novo patients had active disease, whereas 20 patients showed disease remission 1 year after medical treatment with somatostatin analogs (SA) (ten patients) or surgery (ten patients). Thirty healthy subjects matched for age, gender, and body surface area were enrolled as controls. Results: In both active (A) and controlled (C) patients, creatinine clearance (P!0.001) and citrate (P!0.05) and oxalate levels (P!0.001) were higher, whereas filtered Na (P!0.001) and K (P!0.001) fractional excretions were lower than those in the controls. Urinary Ca (P!0.001) and Ph (P!0.05) levels were significantly increased compared with the controls, and in patients with disease control, urinary Ca (P!0.001) levels were significantly reduced compared with active patients. Microalbuminuria was significantly increased in active patients (P!0.05) compared with controlled patients and healthy control subjects. The longitudinal (P!0.05) and transverse (P!0.05) diameters of kidneys were significantly higher than those in the controls. In all patients, the prevalence of micronephrolithiasis was higher than that in the controls (P!0.001), and was significantly correlated to disease duration (rZ0.871, P!0.001) and hydroxyproline values (rZ0.639, P!0.001). Conclusions:The results of the current study demonstrated that acromegaly affects both renal structure and function. The observed changes are not completely reversible after disease remission.

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Sodium potassium dependent ATPase in hypophysectomized rats: Response to growth hormone, triiodothyronine, and cortisone

Cited by 36 publications

References 16 publications

Growth Hormone and Body Composition

Growth Hormone and Body Composition

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

The kidney in acromegaly: renal structure and function in patients with acromegaly during active disease and 1 year after disease remission

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