2016
DOI: 10.18632/aging.101150
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Abstract: At present, there are no reports on the relationship between fluoride-induced apoptosis and endoplasmic reticulum (ER) stress (ER stress) in the spleen of human and animals in vivo and in vitro. Therefore, the aim of this study was to define sodium fluoride (NaF)-induced apoptosis mediated by ER stress in the spleen of mice in vivo and in vitro. Apoptosis and expression levels of the ER stress-related proteins were detected by flow cytometry and western blot, respectively. The results showed that NaF treatment… Show more

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Cited by 49 publications
(17 citation statements)
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“…Spleen. Spleen of mice exposed to fluoride increased lymphocytes apoptosis, which was consistent with NaFcaused endoplasmic reticulum stress (46). Broilers exposed to high doses of fluoride presented endoplasmic reticulum stress in spleen cells that in turn leads to apoptosis as well (83).…”
Section: Bonesupporting
confidence: 67%
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“…Spleen. Spleen of mice exposed to fluoride increased lymphocytes apoptosis, which was consistent with NaFcaused endoplasmic reticulum stress (46). Broilers exposed to high doses of fluoride presented endoplasmic reticulum stress in spleen cells that in turn leads to apoptosis as well (83).…”
Section: Bonesupporting
confidence: 67%
“…Splenic lymphocytes from mice were exposed to NaF (0, 100, 200, and 400 μmol/l) in vitro for 24 and 48 h (46,47). NaF induced lymphocyte apoptosis, which was promoted by decreasing mitochondria transmembrane potential, upregulation of Bax, Bak, Fas, FasL, caspase 9, caspase 8, caspase 7, caspase 6 and caspase 3 protein expression and down-regulation of Bcl-2 and Bcl-xL protein expression (46,47). The above-mentioned data suggested that NaFinduced apoptosis in splenic lymphocytes could be mediated by mitochondrial intrinsic pathway and death receptor pathways.…”
Section: In Vitro Studiesmentioning
confidence: 99%
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“…It also induces formation of free radicals disturb the action of the antioxidants. That disturbance leads to an oxidative stress damages the metabolism of all compounds found in the cell and causes apoptosis [32,33,34] .…”
Section: Discussionmentioning
confidence: 99%
“…As we all know that F is necessary in lots of physiological activities. However, previous literatures have demonstrated that over-consumption of F not only damaged hard tissues, such as bone [3,4] and tooth [5,6], but also soft tissues, such as liver, kidney, thyroid, testis, uterus, and ovary [7][8][9][10][11]. Recently, literatures have suggested that over-intake F had intestinal toxicity [12,13], while the underlying mechanisms of the intestinal toxicity of F are unclear.…”
Section: Introductionmentioning
confidence: 99%