Archives of Otolaryngology - Head and Neck Surgery
 1964
DOI: 10.1001/archotol.1964.00750040273006
|Get access via publisher |Summarize |Cite
|
Sign up to set email alerts

Sodium Fluoride For Arrest of Otosclerosis: Theoretical Considerations

G. E. SHAMBAUGH1,
Andrew M. Scott2
Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
37
3
1
0

Citation Types

0
6
0
0

Year Published

1965
1965
2025
2025

Publication Types

Select...
35
6

Relationship

1
40

Authors

Journals

citations

Cited by 41 publications

(6 citation statements)
references

References 0 publications

0
6
0
0
Order By: Relevance
“…Sodium fluoride was a widely used medical treatment for otosclerosis in the latter half of the twentieth century. Several studies have shown a modest reduction in the progression of sensorineural hearing loss with fluoride treatment [6,20,21,22, 23,24], and since the side effects are generally benign, fluoride continues to be employed for treatment of otosclerosis in some centers.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Sodium fluoride was a widely used medical treatment for otosclerosis in the latter half of the twentieth century. Several studies have shown a modest reduction in the progression of sensorineural hearing loss with fluoride treatment [6,20,21,22, 23,24], and since the side effects are generally benign, fluoride continues to be employed for treatment of otosclerosis in some centers.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In general, treatment consists of hearing aids or removing the stapes superstructure and replacing it with a prosthesis: stapedectomy or stapedotomy. In 1964, Shambaugh and Scott were the first to propose sodium fluoride for the treatment of otosclerosis (2). Sodium fluoride is thought to stabilize the pathologically imbalanced bone metabolism by neutralizing proteolytic enzymes that are involved in the disease process (3).…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Shambaugh & Scott 11 were the first to use sodium fluoride to treat osteodystrophy and propose the prescription of moderate doses of this drug to promote recalcification and deactivation of the active otospongiosis sites.…”
Section: Introductionmentioning
confidence: 99%
“…Double-blind controlled clinical trials have also shown the efficacy of sodium fluoride in stabilizing hearing thresholds (sensorineural component of hearing) 9 , 10 , 11 , 12 , 14 .…”
Section: Introductionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
scite logo

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Status

Copyright © 2026 Scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.

Research Solutions Logo