Sodium dodecyl sulfate as a viral inactivator and future perspectives in the control of small ruminant lentiviruses

Abstract

Infections by small ruminant lentiviruses (SRLVs) affect goats and sheep causing chronic multisystemic diseases that generate great economic losses. The caprine lentivirus (CLV) and the ovine lentivirus (OLV) present tropism for cells of the monocyte/macrophage lineage, which are directly associated with the main route of transmission through the ingestion of milk and colostrum from infected animals. In this manner, controlling this route is of paramount importance. Currently, researches have investigated the use of chemical additives in milk that can preserve colostrum or milk and inactivate microbiological agents. Among the compounds, sodium dodecyl sulfate (SDS) has been shown to be satisfactory in the chemical inactivation of HIV and CLV in milk, and also as a biocide in goat colostrum.

Unusual Compatibility of N‐Reacetylated Oligochitosan with Sodium Dodecyl Sulfate in Aqueous Solution with a Wide Range of the Solution pH

“…In addition, it should be mentioned that in spite of a relatively high cytotoxicity of SDS found toward cow lung endothelial cells, the daily safe consumption of SDS from house‐hold and cosmetic compositions and toothpaste may reach the value of 1 mg SDS/kg/day, as it has been found so far. [ 71 ]…”

“…In addition, it should be mentioned that in spite of a relatively high cytotoxicity of SDS found toward cow lung endothelial cells, the daily safe consumption of SDS from house-hold and cosmetic compositions and toothpaste may reach the value of 1 mg SDS/kg/day, as it has been found so far. [71] In this respect, further investigations are required to determine the cytotoxicity of RA-oligoCHI toward epidermal keratonocytes in order to evaluate its applicability in the SDS-containing pharmaceutical hydrocolloids, lotions, shampoos and other cosmetic compositions designed for topical applications since the cytotoxicity of SDS can differ for different cells at different dosages. [72]…”

Avaliação da atividade antifúngica de nanopartículas de prata em fungos do gênero Candida isolados de lesões de indiví-duos com HIV

“…Tabela 2. Concentração Inibitória Mínima (MIC) dos isolados fúngicos.No entanto, não foi possível investigar especificidades fenotípicas dessas cepas que pudessem diferenciá-las daquelas condizentes com o estado de saúde tecidual.Além disso, sabe-se que as nanopartículas de prata são relativamente mais tóxicas a células saudáveis do que os íons de prata(SAMBALE et al, 2015), o que pode resultar em danos aos microrganismos presentes na comunidade microbiana saudável(DURÁN et al, 2019) e às várias células hospedeiras(TRIPATHI et al, 2017).o SDS em contato com as células, podem causar efeitos físicos e bioquímicos na membrana celular, podendo interferir em sua estrutura(SOUZA et al, 2019).Os possíveis efeitos citotóxicos dependem da concentração utilizada e da razão molar lipídio / surfactante; onde quando em baixa concentração de surfactante, tende a aumentar a permeabilidade celular; no entanto, quando esta razão molar, for mais elevada pode causar a lise celular(SOUZA et al, 2019), porém ainda há a necessidade de avaliar a citotoxicidade em células humanas.…”