“…P2X3, Bernier et al ., ) and acid‐sensing ion channels (in particular ASIC3; Deval and Lingueglia, ). Channels expressed in nociceptors with a role in controlling sensory neuron excitability include the voltage‐gated Na + channel subtypes Na V 1.1, Na V 1.3, Na V 1.6, Na V 1.7, Na V 1.8 and Na V 1.9 (Cardoso and Lewis, ); Ca V 3 voltage‐gated Ca 2+ channel isoforms (François et al ., ) and K + channels such as two‐pore‐domain (K2P) TREK and TRESK (Mathie and Veale, ) and KCNQ (Kv7) M channels (Du et al ., ). Channels such as Ca v 2.2 (Patel et al ., ) and associated α2δ auxiliary subunits (Gong et al ., ) have a key role in regulating neurotransmitter and neuropeptide release at central terminals in the dorsal horn of the spinal cord.…”