Sodium butyrate ameliorates neurotoxicity and exerts anti-inflammatory effects in high fat diet-fed mice

Bayazid, Al Borhan; Kim, Jae Gon; Azam, Shofiul; Jeong, Soo Ah; Kim, Da Hee; Park, Chaewon; Lim, Beong Ou

doi:10.1016/j.fct.2021.112743

Cited by 30 publications

(45 citation statements)

References 38 publications

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“…We showed the results of anti-inflammatory efficacy and inflammation relief in colitis using FB among metabolites. Additionally, we have also recently derived the results that FB relieves inflammation in the brain [ 4 , 29 ]. In these results, it is hypothesized that FB showed an overall anti-inflammatory effect on the DSS-induced mice and on RAW 264.7 cells.…”

Section: Discussionmentioning

confidence: 99%

“…UC models have been developed to study pathogenic studies and genes, such as gene knockout (KO), interleukin (IL)-2 receptor-alpha, IL-10, T cell receptor, and tumor necrosis factor (TNF)-α untranslated domain [ 3 , 4 , 5 ]. UC induced by heparin-like polysaccharides, such as dextran sulfate sodium (DSS), is simple, and it has the quality and the uniform form of the lesion in the colon.…”

Section: Introductionmentioning

confidence: 99%

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The Anti-Inflammatory Activities of Fermented Curcuma That Contains Butyrate Mitigate DSS-Induced Colitis in Mice

et al. 2022

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Inflammatory bowel disease is characterized by a radical imbalance of inflammatory signaling pathways in the gastrointestinal tract, and it is categorized into two diseases, such as Crohn’s disease and ulcerative colitis. In this study, we investigated anti-inflammatory activities using fermented Curcuma that contains butyrate (FB). Nitric oxide production in RAW 264.7 cells and the expression of inducible nitric oxide synthase in the intestinal mucosa appears to be enhanced in active ulcerative colitis. Here, the cytotoxicity, physiological activity, and anti-inflammatory efficacy of FB in colitis animals were investigated. To verify the anti-inflammatory effect, this study was conducted using the dextran sulfate sodium (DSS)-induced colitis mice model. As a result, non-toxicity was confirmed, and anti-inflammatory effects were revealed by inducing a reduction of LPS-induced NO production. In the DSS-induced colitis, reduced weight was recovered and a decrease in inflammatory factors Ig-E and TNF-α in the mesenteric lymph node (MLN) and spleen was induced, and it was confirmed to help with the morphological remodeling of the intestine. In conclusion, this paper suggests that FB can help to alleviate intestinal inflammation and to improve the intestinal environment, with the help of morphological remodeling.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Activities of Fermented Curcuma That Contains Butyrate Mitigate DSS-Induced Colitis in Mice

et al. 2022

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“…P-53 KO neurons were able to completely counteract the toxicity of C9orf72(PR)50 accumulation [ 69 ]. Furthermore, the impaired mitochondrial function also disrupts autophagic clearance (i.e., mitophagy) and induces aggregation of filamentous or misfolding proteins, e.g., amyloid beta (Aβ) and α-synuclein, leading to Alzheimer’s disease and Parkinson’s disease [ 70 ]. However, excess of cytochrome c, a component of ETC release due to oxidative stress and/or increased P-53 secretion, is an indication of damaged mitochondrial membrane potential [ 2 ].…”

Section: Metabolism Of Quercetinmentioning

confidence: 99%

“…and mediators. Inflammation is an inevitable immune response towards antigens, pathogens, damaged cells, and so on [ 70 ]. Precisely, an adverse effect of immune response is called inflammation, and the cells require homeostasis other than the hyperactivation of inflammatory markers.…”

Section: Metabolism Of Quercetinmentioning

confidence: 99%

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Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1

Bayazid

Lim

2022

Nutrients

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Berries are well-known fruits for their antioxidant effects due to their high content of flavonoids, and quercetin is one of the potent bioactive flavonoids. Although oxidative stress is an inevitable outcome in cells due to energy uptake and metabolism and other factors, excessive oxidative stress is considered a pivotal mediator for the cell death and leads to the progression of neurodegenerative diseases (NDDs). Furthermore, oxidative stress triggers inflammation that leads to neuronal cell loss. Alzheimer’s, Parkinson’s, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and so on are the main neurodegenerative diseases. Hence, AD and PD are the most affected NDDs and cause the most lethality without any effective cure. Since AD and PD are the most common NDDs, therefore, in this study, we will describe the effect of oxidative stress on AD and PD. Targeting oxidative stress could be a very effective way to prevent and cure NDDs. Thus, the nuclear factor erythroid 2–related factor 2 (Nrf2) and heme oxygenase-1 (HO1) are potent endogenous antioxidant modulatory pathways, which also show cytoprotective activities. Modulation of Nrf2/HO1 signaling pathways through a biological approach could be an effective way to treat with NDDs. Quercetin is a natural polyphenol, which protects neurodegeneration, remarkably by suppressing oxidative stress and inflammation. Thus, quercetin could be a very effective agent against NDDs. We will discuss the benefits and challenges of quercetin to treat against NDDs, focusing on molecular biology.

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Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis

et al. 2023

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Sodium butyrate ameliorates neurotoxicity and exerts anti-inflammatory effects in high fat diet-fed mice

Cited by 30 publications

References 38 publications

The Anti-Inflammatory Activities of Fermented Curcuma That Contains Butyrate Mitigate DSS-Induced Colitis in Mice

The Anti-Inflammatory Activities of Fermented Curcuma That Contains Butyrate Mitigate DSS-Induced Colitis in Mice

Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1

Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis

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