Socio-demographic determinants of beliefs about  COVID-19 vaccine in Nigeria

Iheanacho, Chinonyerem O.; Enechukwu, Okechukwu Harrison; Aguiyiikeanyi, Chinelo Nneka

doi:10.29228/jrp.83

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…[24] Socio-demographics are now widely recognized determinants of health associated variables. [24][25][26][27] is commonly results from social, biological, and functional changes that occur with age and other socio-demographics.…”

Section: Discussionmentioning

confidence: 99%

Point of care testing and health parameter assessment in community pharmacy setting

Eze

Iheanacho

et al. 2023

AJPPS

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Objectives: Health screening is essential for early detection and prompt management of diseases, particularly chronic conditions. The study assessed and classified participants’ health parameters according to standard classifications. Associations between participants’ socio-demographics and observed health parameters were also assessed. Materials and Methods: A cross-sectional survey of 400 adults was performed in a community pharmacy in Nigeria, using a pretested questionnaire. Health parameters were measured and analyzed descriptively with SPSS version 24. Chi-square tests and Pearson’s correlation analysis were also performed (P < 0.05). Results: A 100% response rate was recorded in the study. Mean temporal temperature (TT) and respiratory rate (RR)/minute were 36.627°C ± 0.3143 and 18.20 ± 3.261, respectively. Almost half, (195; 48.8%) were 20–39-years-old. Almost all (399/400; 99.8%) had normal TT, normal RR (347/400; 86.8%), fasting blood glucose (FBG) (326/400; 81.5%), and about a third had pains (156/400; 39.0%). Age was significantly associated with RR (P = 0.008) and FBG (P = 0.002). Gender and educational levels were significantly associated with RR (P = 0.003) and FBG (P = 0.001), respectively. A weak negative correlation (r = −0.018; P = 0713) between participants’ FBG and TT was observed. FBG was negatively correlated with pain level (r = −0.091; P = 0.068), while pain level was negatively correlated with TT (r = −0.010; P = 0.832). Relationship between TT and RR showed weak positive correlation (r = 0.023; P = 0.637). Conclusion: Health parameters were mostly normal, but selectively associated with socio-demographics. The study shows the role of community pharmacists in routine point of care testings, and findings suggest a focus of healthcare on the correlation of age, gender and educational level with FBG and RR.

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Section: Discussionmentioning

confidence: 99%

Point of care testing and health parameter assessment in community pharmacy setting

Eze

Iheanacho

et al. 2023

AJPPS

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“…Meanwhile, there is need for more data from pharmacovigilance, to ascertain the actual distribution and prevalence of these events. Socio-demographics is also a major influencing factor for beliefs about COVID-19 vaccine [ 33 ]. A good knowledge of the socio-demographic distribution of potential VITT is necessary for strategic vaccination to prevent or reduce its occurrence.…”

Section: Discussionmentioning

confidence: 99%

Immunogenicity and clinical features relating to BNT162b2 messenger RNA COVID-19 vaccine, Ad26.COV2.S and ChAdOx1 adenoviral vector COVID-19 vaccines: a systematic review of non-interventional studies

Iheanacho

Eze

2022

Futur J Pharm Sci

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Background Vaccination against Coronavirus disease 2019 (COVID-19) is an important means of controlling the pandemic, however they are expected to stimulate immune responses when administered to confer immunity. In this review, we evaluated the clinical and laboratory features associated with BNT162b2 messenger RNA COVID-19 vaccine, Ad26.COV2.S and ChAdOx1 adenoviral vector COVID-19 vaccines, to determine their immunogenicity. Demographic distribution of pathogenic autoimmune response and time interval between vaccination and onset of symptoms were also assessed. This was to identify; persons at risk of developing auto-immune reactions and markers to enhanced occurrence of this event. Main body Using relevant keywords, search was conducted in the databases of PubMed, Scopus, Web of Science and Google scholar from November 2020 to May 31, 2021. Additional article was also identified through hand-searching of reference lists, and the review was conducted in line with Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines 2009. Study outcome measures were presence of antibodies after vaccination and evidence of autoimmune reactions, therefore studies relating these measures were considered eligible for this review. Studies showed stimulation of immune response with administration of BNT162b2 mRNA vaccine, ChAdOx1 and Ad26.COV2-S adenovirus vector-based vaccines. Aside SARS-CoV-2 spike protein antibodies, elevated D-dimers, presence of PF4 and low fibrinogen were most commonly seen laboratory features in persons with autoimmune reactions following vaccination. In addition, thrombotic thrombocytopenia was the commonest clinical features observed with ChAdOx1 and Ad26.COV2-S adenovirus vector-based vaccines. Findings from this study also suggest higher susceptibility of women of 22–60 years to the pathogenic immunogenicity that may particular result from exposure to ChAdOx1 and Ad26.COV2-S adenovirus vector-based vaccines. Time interval of 4–37 days was mostly observed between vaccination and occurrence of a symptom. Conclusion Immune thrombotic thrombocytopenia and other PF4 dependent syndrome are likely associated with ChAdOx1 and Ad26.COV2.S adenovirus vector vaccines, mostly occurring in women usually within 4–37 days of first dose of vaccine. Enhanced knowledge about vaccine adverse effects and its distribution is crucial for effective vaccination strategies.

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