Developmental Psychopathology 2016
DOI: 10.1002/9781119125556.devpsy408
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Abstract: Vulnerability and resilience are intertwined yet unraveling constructs in the allostatic load literature centered on stress‐disease pathways. In examining this paradigm shift, this chapter focuses on allostatic load indices of multisystemic physiological dysregulations among marginalized populations. Social inequalities reviewed include early adversity, socioeconomic health gradients, race/ethnicity and discrimination, Brazil's shifting economy, the struggles of North American and Australian Indigenous peoples… Show more

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Cited by 28 publications
(33 citation statements)
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“…On a 0-6 range of allostatic load, movement from a poor to a middle-class childhood would reduce allostatic load in adulthood by about a third of a risk factor. Given the rapidly expanding evidence that elevated allostatic load marks accelerated aging (2,30,31), this prospective longitudinal evidence for social inequalities in allostatic load may prove fundamental in understanding how poverty gets under the skin and stays there.…”
Section: Discussionmentioning
confidence: 99%
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“…On a 0-6 range of allostatic load, movement from a poor to a middle-class childhood would reduce allostatic load in adulthood by about a third of a risk factor. Given the rapidly expanding evidence that elevated allostatic load marks accelerated aging (2,30,31), this prospective longitudinal evidence for social inequalities in allostatic load may prove fundamental in understanding how poverty gets under the skin and stays there.…”
Section: Discussionmentioning
confidence: 99%
“…Another limitation is the allostatic load index, which reflects the simple summation of a set of dichotomous indicators of dysfunction across multiple, biological systems. This crude index, which appears to reflect some aspects of chronic wear and tear on the body, likely does not fully capture the more dynamic and systematic interplay between multiple biological systems as they are challenged by chronic environmental demands (26)(27)(28)(29)(30)(31).…”
Section: Discussionmentioning
confidence: 99%
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“…When prolonged, this multisystemic response exerts ‘wear and tear’ on various cellular components, accelerating age‐related functional decline and susceptibility to disease affecting multiple organ systems – colloquially termed ‘multimorbidity’. Together, these systems interact with energy‐producing mitochondria, represent the cellular basis for ‘multimorbidity’, and constitute the mechanisms of vulnerability and resilience to environmental challenge .…”
Section: Case Study: a Fairly Typical Person With ‘Multimorbidity’mentioning
confidence: 99%