Abstract:BackgroundNumerous factors that contribute to malignant glioma invasion have been identified, but the upstream genes coordinating this process are poorly known.MethodsTo identify genes controlling glioma invasion, we used genome-wide mRNA expression profiles of primary human glioblastomas to develop an expression-based rank ordering of 30 transcription factors that have previously been implicated in the regulation of invasion and metastasis in cancer.ResultsUsing this approach, we identified the oncogenic tran…
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