Smooth muscle role on pulmonary arterial function during acute pulmonary hypertension in sheep

Bia, Daniel; Armentano, Ricardo L.; Craiem, Damián; Grignola, Juan C.; Ginés, Fernando; Simon, Alain; Levenson, Jaime

doi:10.1111/j.1365-201x.2004.01294.x

Cited by 22 publications

(79 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This method, described by Bauer et al consists in progressively augmenting the viscous modulus (see (2)) until the hysteresis loop is minimized, while maintaining a clockwise rotation [9][10][11]. The value that best fits those requirements is considered the viscous modulus [8].…”

Section: Discussionmentioning

confidence: 99%

“…In order to characterize the biomechanical behavior and to calculate the viscoelastic parameters, the venous wall is represented using the KelvinVoigt, according to which the total pressure in the wall can be divided into an elastic and a viscous component [8] as follows: The viscous component is proportional to the first derivative of the diameter with respect to time ( / ), and so (1) can be rewritten as…”

Section: Discussionmentioning

confidence: 99%

“…In order to characterize the venous wall viscosity, the viscous term is subtracted from the total pressure, seeking the minimization of the hysteresis area [8]. This method, described by Bauer et al consists in progressively augmenting the viscous modulus (see (2)) until the hysteresis loop is minimized, while maintaining a clockwise rotation [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Structural and Functional Properties of Venous Wall: Relationship between Elastin, Collagen, and Smooth Muscle Components and Viscoelastic Properties

Zócalo¹,

Bia²,

Cabrera-Fischer

et al. 2013

ISRN Physiology

View full text Add to dashboard Cite

The aims of this work were (1) to analyze the viscoelastic behavior of different venous segments and their differences, considering the structural characteristics (elastin, collagen, and smooth muscle content) of the venous wall; (2) to analyze the venous biomechanical behavior by means of the histological characteristics of the veins. Nine healthy male Corriedale sheep were included. One vein was selected from each animal to evaluate its biomechanical properties: (a) anterior vena cava, (b) right jugular vein, and (c) right femoral vein. Each selected vein was instrumented with pressure and diameter sensors. After excision, a small ring-shaped sample was set apart from each segment for histological analysis. The amounts of elastin, collagen and smooth muscle were correlated to calculated biomechanical parameters (high-and low-pressure compliance and viscosity). Conclusions are the following: (1) the viscoelastic behavior of the venous wall varies depending on the vascular territory, and it is associated with the variation of the histological structure. These differences involve muscle (both smooth and striated), elastin, and collagen contents. (2) In addition, the quantity of collagen was negatively correlated with high-and low-pressure compliances, and (3) the smooth muscle content was higher in peripheral veins and is positively correlated with venous wall viscosity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Structural and Functional Properties of Venous Wall: Relationship between Elastin, Collagen, and Smooth Muscle Components and Viscoelastic Properties

Zócalo¹,

Bia²,

Cabrera-Fischer

et al. 2013

ISRN Physiology

View full text Add to dashboard Cite

show abstract

“…Femoral artery diameter was measured using the ultrasonic technique routinely used in our laboratory. 4, 17 To this end, the right femoral artery was dissected at its origin, preserving the perivascular adipose tissue, and a pair of ultrasonic crystals (5 MHz, 2-mm diameter) was sutured to the vessel. Ultrasonic signals were visualized on an oscilloscope screen (Tektronix TOS-220, Tektronix Inc, Beaverton, OR USA).…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…Afterwards, the diameter signal was calibrated in millimeters using the sonomicrometer calibration facility. 17 Cardiac output was measured using a Swan-Ganz catheter positioned in the pulmonary trunk via the right jugular vein. The flow stability was monitored with an ultrasonic flow-meter developed for animal use (Transonic Systems Inc, Ithaca, NY, USA).…”

Section: In Vivo Studiesmentioning

confidence: 99%

Effects of Removing the Adventitia on the Mechanical Properties of Ovine Femoral Arteries In Vivo and In Vitro

Fischer

Santana

Zócalo

et al. 2010

Circ J

View full text Add to dashboard Cite

Background:The aims were to characterize in muscular arteries (a) the passive and active effects of the adventitia on vessel biomechanical properties and conduit function (CF), and (b) potential differences between the adventitial role in elastic and muscular arteries. Methods and Results:Ovine femoral arteries were studied in vivo and in vitro (reduced smooth muscle-tone) in a circulation mock-up during hemodynamic conditions similar to those found in vivo. Pressure and diameter were assessed before and after removing the adventitia. The arterial compliance, distensibility, stiffness β-index and CF were quantified. Results were compared with those obtained in brachiocephalic trunks. In vivo, after removing the adventitia there was a nonsignificant diameter reduction and an increase in stiffness (P<0.05). The CF decreased in the early recordings (P<0.02). In vitro, there were no biomechanical changes but vascular dilatation after the adventitia removal. Biomechanical changes associated with the adventitia removal were higher in muscular arteries, whereas diameter changes were major in elastic vessels. Conclusions:After removing the adventitia, (a) the arterial stiffness and CF were modified in vivo only, suggesting the changes could be ascribed to variations in smooth muscle tone, and (b) changes in elastic and muscular arteries were quantitatively different. (Circ J 2010; 74: 1014 - 1022

show abstract

Growth and remodeling in the pulmonary autograft: Computational evaluation using kinematic growth models and constrained mixture theory

Vastmans

Maes

Peirlinck

et al. 2021

Numer Methods Biomed Eng

View full text Add to dashboard Cite

Computational investigations of how soft tissues grow and remodel are gaining more and more interest and several growth and remodeling theories have been developed. Roughly, two main groups of theories for soft tissues can be distinguished: kinematic-based growth theory and theories based on constrained mixture theory. Our goal was to apply these two theories on the same experimental data. Within the experiment, a pulmonary artery was exposed to systemic conditions. The change in diameter was followed-up over time.A mechanical and microstructural analysis of native pulmonary artery and pulmonary autograft was conducted. Whereas the kinematic-based growth theory is able to accurately capture the growth of the tissue, it does not account for the mechanobiological processes causing this growth. The constrained mixture theory takes into account the mechanobiological processes including removal, deposition and adaptation of all structural constituents, allowing us to simulate a changing microstructure and mechanical behavior.

show abstract

Smooth muscle role on pulmonary arterial function during acute pulmonary hypertension in sheep

Cited by 22 publications

References 23 publications

Structural and Functional Properties of Venous Wall: Relationship between Elastin, Collagen, and Smooth Muscle Components and Viscoelastic Properties

Structural and Functional Properties of Venous Wall: Relationship between Elastin, Collagen, and Smooth Muscle Components and Viscoelastic Properties

Effects of Removing the Adventitia on the Mechanical Properties of Ovine Femoral Arteries In Vivo and In Vitro

Growth and remodeling in the pulmonary autograft: Computational evaluation using kinematic growth models and constrained mixture theory

Contact Info

Product

Resources

About