Smooth Muscle Relaxing Drugs and Guinea Pig Ileum

Mukai, Teiichi; Yamaguchi, Eiichi; Goto, Jun; Takagi, Keijiro

doi:10.1016/s0021-5198(19)52860-8

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Aqueous extract of Acanthus monathus inhibited the contractions induced by PGF2α, acetylcholine, oxytocin, serotonin, histamine and calcium chloride in rat uterus (Harquin et al, 2006). When a plant extract exhibit non-receptor specificity being able to inhibit contraction evoked by more than one uterotonic agents, there is a possibility that a downstream mechanisms beyond and common to receptor site could be linked to the extract observed activity (Mukai et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Effect of methanol extract of Anacardium occidentale stem bark on agonist-induced contraction in rat uterine muscle

Omolaso¹

2021

ijs

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Anacardium occidentale (Ao) is widely used in ethnomedicine and the effect on contractility of the gut and heart muscles of laboratory rodents have been established however, its effect on the contractility of uterine muscle has been rarely researched. The present study investigated the effect of stem bark methanolic extract of Anacardium occidentale (AoME) on Isolated Rat Uterus Strips (IRUS). The Anacardium occidentale methanol extract (AoME) was obtained by solvent extraction. The IRUS were suspended in a bath containing 15 ml of De Jalon's solution through a silk connected to a force transducer. A tension of 1.0 g was applied. The strips were allowed to equilibrate for a period of 60–90 min before the commencement of the experiment. The extract (0.025- 0.3mg/ml) added cumulatively did not modify the normal tonus in most of the IRUS used except in one where it feebly contracted it. However, the contractile responses induced by acetylcholine (10-9 -10-5 M) and oxytocin (10-9 -10-5 M) on the IRUS were almost completely blocked by pre-incubated AoME at a concentration of 0.2 mg/ml. Stem bark methanol extract of Anacardium occidentale shifted the log concentration curve of both agonists to the right. The present results report the antagonistic effects of stem bark methanol extract of Anacardium occidentale on oxytocin and acetylcholine-induced contraction in rat uterus strips. Keywords: Anacardium occidentale, Oxytocin, Acetylcholine, Uterus, Smooth muscle

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Section: Discussionmentioning

confidence: 99%

Effect of methanol extract of Anacardium occidentale stem bark on agonist-induced contraction in rat uterine muscle

Omolaso¹

2021

ijs

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“…[93] The potency of the compounds was expressed relative to papaverine, a compound that is known to relax the smooth muscle of the small arteries and thus to cause vasodilation, [94] although they later discovered that papaverine and Diltiazem 94 b display their effects through different modes of action. [95] Table 1 shows that the potency of the cis isomers ranged from 0.8 to 3.5, while for the trans isomers values of < 0.1 to 0.1 were noted. This indicated that there was a clear difference in favor of the cis isomer.…”

Section: Study Of Biological Activitymentioning

confidence: 98%

Synthesis of the 1,5‐Benzothiazepane Scaffold – Established Methods and New Developments

et al. 2023

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The 1,5‐benzothiazepane structure is an important heterocyclic moiety present in a variety of commercial drugs and pharmaceuticals. This privileged scaffold exhibits a diversity of biological activities, including antimicrobial, antibacterial, anti‐epileptic, anti‐HIV, antidepressant, antithrombotic and anticancer properties. Its important pharmacological potential renders research into the development of new and efficient synthetic methods of high relevance. In the first part of this review, an overview of different synthetic approaches toward 1,5‐benzothiazepane and its derivatives is provided, ranging from established protocols to recent (enantioselective) methods that promote sustainability. In the second part, several structural characteristics influencing biological activity are briefly explored, providing a few insights into the structure‐activity relationships of these compounds.

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Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library

Lynch

Sakamuru

Huang

et al. 2021

Biochemical Pharmacology

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Smooth Muscle Relaxing Drugs and Guinea Pig Ileum

Cited by 5 publications

References 25 publications

Effect of methanol extract of Anacardium occidentale stem bark on agonist-induced contraction in rat uterine muscle

Effect of methanol extract of Anacardium occidentale stem bark on agonist-induced contraction in rat uterine muscle

Synthesis of the 1,5‐Benzothiazepane Scaffold – Established Methods and New Developments

Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library

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