Aim. Arterial smooth muscle cells (SMCs) may accumulate cholesterol and modify their phenotypic behavior becoming foam cells. We aimed to characterize the role of HDL 3 and the ATP binding cassette transporter ABCA1 in this process. Methods. We evaluated the cholesterol-induced phenotypic changes in SMCs isolated from wild type (WT) and ABCA1 knock out (KO) mice and how HDL 3 affects these changes. Results. Cholesterol loading downregulates the expression of ACTA2 (SMC-marker), and increases the expression of…
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